Advertisement
Brief report| Volume 27, ISSUE 9, P1053-1056, May 01, 1990

Download started.

Ok

Electrocardiographic effects of amitriptyline in therapeutic doses on 24-hr monitoring (Holter) with correlation to plasma levels

  • Pinkhas Sirota
    Correspondence
    Address reprint requests to Dr. Pinkhas Sirota, Director of Department 6A, Yehuda Abarbanel Mental Health Center, Bat, Yam, Israel.
    Footnotes
    Affiliations
    Department 6A, Yehuda Abarbanel Mental Health Center, Bat Yam, and the Sackler School of Medicine, Tel Aviv University, Israel
    Search for articles by this author
  • Jacob Ori
    Footnotes
    Affiliations
    Department of Medicine “C” and the Cardiology Service, Hasharon Hospital, Golda Meir Medical Center, Petah Tiqva, and the Sackler School of Medicine, Tel Aviv University, Israel
    Search for articles by this author
  • Klara Schild
    Footnotes
    Affiliations
    Department 6A, Yehuda Abarbanel Mental Health Center, Bat Yam, and the Sackler School of Medicine, Tel Aviv University, Israel
    Search for articles by this author
  • Shmuael Appel
    Footnotes
    Affiliations
    Department of Medicine “C” and the Cardiology Service, Hasharon Hospital, Golda Meir Medical Center, Petah Tiqva, and the Sackler School of Medicine, Tel Aviv University, Israel
    Search for articles by this author
  • Simcha Brandis
    Footnotes
    Affiliations
    Department of Medicine “C” and the Cardiology Service, Hasharon Hospital, Golda Meir Medical Center, Petah Tiqva, and the Sackler School of Medicine, Tel Aviv University, Israel
    Search for articles by this author
  • Izhar Zahavi
    Footnotes
    Affiliations
    Department of Medicine “C” and the Cardiology Service, Hasharon Hospital, Golda Meir Medical Center, Petah Tiqva, and the Sackler School of Medicine, Tel Aviv University, Israel
    Search for articles by this author
  • Author Footnotes
    ∗ We wish to thank Drs. H. Belmaker and M. Segal from the Ezrat-Nashim Psychiatric Centre, Jerusalem, for the determination of the blood levels of amitriptyline.
DOI:https://doi.org/10.1016/0006-3223(90)90041-Y
Electrocardiographic effects of amitriptyline in therapeutic doses on 24-hr monitoring (Holter) with correlation to plasma levels
Previous ArticleDecreased episodic violence and increased control of dissociation in a carbamazepine-treated case of multiple personality
Next ArticleSigns and symptoms associated with cataplexy in narcolepsy patients
      This paper is only available as a PDF. To read, Please Download here.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Biological Psychiatry
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Register: Create an account
      Institutional Access: Sign in to ScienceDirect

      References

        • Alexander C.S.
        • Nino A.
        Cardiovascular complications in young patients taking psychotropic drugs.
        Am Heart J. 1969; 78: 757-769
        • Beck A.T.
        • Beamsderter A.A.
        Assessment of depression: The depression inventory.
        in: Pichot P. Psychological Measurements in Psychopharmacology: Modern Problems in Pharmacopsychiatry. S Karger, Basel1974: 151
        • Boehnert M.T.
        • Lovejoy F.H.
        Value of the QRS duration versus the serum drug level in predicting seizures and ventricular arrhythmias after an acute overdose of tricyclic antidepressants.
        N Engl J Med. 1985; 313: 474-479
        • Boston Collaborative Drug Surveillance Program
        Adverse reactions to the tricyclic-antidepressant drugs.
        Lancet. 1972; i: 529-531
        • Brunswick D.J.
        • Needelman B.
        • Mendels J.
        Specific radioimmunoassay of amitriptyline and nortriptyline.
        Br J Clin Pharmacol. 1979; 7: 343-348
        • Burckhardt D.
        • Raeder E.
        • Muller V.
        • Imhof P.
        • Neubauer H.
        Cardiovascular effects of tricyclic and tetracyclic antidepressants.
        JAMA. 1978; 239: 213-216
        • Burgess C.D.
        • Montgomery S.
        • Wadsworth J.
        • Turner P.
        Cardiovascular effects of amitriptyline, mianserin, zimelidine and nomifensine in depressed patients.
        Postgrad Med J. 1979; 55: 704-708
        • Burrows G.D.
        • Vohra J.
        • Dumovic P.
        TCA drugs and cardiac conduction.
        Prog Neuropsychopharmacol Biol Psychiatry. 1977; 1: 329-335
        • Coull D.C.
        • Crooks J.
        • Dingwall Fordyce I.
        • Scott A.M.
        Amitriptyline and cardiac disease. Risk of sudden death identified by monitoring system.
        Lancet. 1970; ii: 590-591
        • Fowler N.O.
        • McCall D.
        • Chou T.C.
        • Holmes J.C.
        • Hanenson I.B.
        Electrocardiographic changes and cardiac arrhythmias in patients receiving psychotropic drugs.
        Am J Cardiol. 1976; 37: 223-230
        • Garvey M.J.
        • Tauson V.B.
        • Johnson R.A.
        • Valentine R.H.
        • Cooper T.B.
        Elevated plasma tricyclic levels with therapeutic dose of imipramine.
        Am J Psychiatry. 1984; 141: 853-856
        • Giardina E.G.V.
        • Bigger Jr, J.T.
        • Glassman A.H.
        • Perel J.M.
        • Kantor S.J.
        The electrocardiographic and anti-arrhythmic effects of imipramine hydrochloride at therapeutic plasma concentrations.
        Circulation. 1979; 60: 1045-1052
        • Giardina E.G.V.
        • Bigger Jr, J.T.
        Antiarrhythmic effect of imipramine hydrochloride in patients with ventricular premature complexes without psychological depression.
        Am J Cardiology. 1982; 50: 172-179
        • Glassman A.H.
        Cardiovascular effects of tricyclic antidepressants.
        Ann Rev Med. 1984; 35: 503-511
        • Glassman A.H.
        • Roose S.P.
        • Giardina E.-G.V.
        • Bigger Jr, J.T.
        Cardiovascular effects of tricyclic antidepressants.
        in: Meltzer H.Y. Psychopharmacology: The Third Generation of Progress. Raven Press, New York1987: 1437
        • Hollister L.E.
        Treatment of depression with drugs.
        Ann Int Med. 1978; 89: 78-84
        • Jefferson J.W.
        Treating affective disorder in the presence of cardiovascular disease.
        Psychiatr Clin North Am. 1983; 6: 141-155
        • Kantor S.J.
        • Bigger Jr, J.T.
        • Glassman A.H.
        • Macken D.L.
        • Perel J.M.
        Imipramine-induced heart block.
        JAMA. 1975; 231: 1364-1366
        • Moir D.C.
        • Dingwall Fordyce I.
        • Weir R.D.
        Medicines evaluation and monitoring group. A follow-up study of cardiac patients receiving amitriptyline.
        Eur J Clin Pharmacol. 1973; 6: 98-101
        • Niemann J.T.
        • Bessen H.A.
        • Rothstein R.J.
        • Lahis M.M.
        Electrocardiographic criteria for tricyclic antidepressant cardiotoxicity.
        Am J Cardiol. 1986; 57: 1154-1159
        • Petit J.M.
        • Spiker D.G.
        • Ruwitch J.F.
        • Ziegler V.E.
        • Weiss A.N.
        • Biggs J.T.
        Tricyclic antidepressant plasma levels and adverse effects after overdose.
        Clin Pharmacol Ther. 1977; 21: 47-51
        • Roose S.P.
        • Glassman A.H.
        • Giardina E.-G.V.
        • Walsh B.T.
        • Woording S.
        • Bigger T.
        Tricyclic antidepressants in depressed patients with cardiac conduction disease.
        Arch Gen Psychiatry. 1987; 44: 273-275
        • Salzman C.
        Clinical use of antidepressant blood levels and electrocardiogram.
        N Engl J Med. 1985; 313: 512-513
        • Scolling M.J.
        • Robinson D.S.
        • Nies A.
        Cardiotoxicity of amitriptyline.
        Lancet. 1972; ii: 1202
        • Smith R.B.
        • Rusbatch B.J.
        Amitriptyline and heart block.
        Br Med J. 1976; 3: 311
        • Spiker D.G.
        • Weiss A.N.
        • Cahng S.S.
        • Ruwitch Jr, J.F.
        • Biggs J.T.
        Tricyclic antidepressant overdose: Clinical presentation and plasma levels.
        Clin Pharmacol. 1975; 18: 539-546
        • Task Force on the Use of Laboratory Tests in Psychiatry
        Tricyclic antidepressants blood level measurements and clinical outcome: An APA Task Force Report.
        Am J Psychiatry. 1985; 142: 155-162
        • White K.
        • O'Leary J.
        • Razani J.
        • Rebal R.
        • Palmer R.
        Electrocardiographic effects of tranylcypromine vs. amitriptyline.
        J Clin Psychiatry. 1983; 44: 91-93
        • Wilkerson R.D.
        Anti-arrhythmic effects of tricyclic anti-depressant drugs in ouabain-induced arrhythmias in the dog.
        J Pharmacol Exp Ther. 1978; 203: 666-674
        • Williams J.B.W.
        Diagnostic and Statistical Manual of Mental Disorders (DSM III-R). American Psychiatric Association Press, Washington1987 (ed 4, revised)
        • Ziegler V.E.
        • Biggs J.T.
        Electrocardiographic findings in patients undergoing amitriptyline treatment.
        Dis Nerv Sys. 1977; 38: 697-699

      Article info

      Publication history

      Received in revised form: October 15, 1989
      Received: March 7, 1989

      Identification

      DOI: https://doi.org/10.1016/0006-3223(90)90041-Y

      Copyright

      © 1990 Published by Elsevier Inc.

      ScienceDirect

      Access this article on ScienceDirect

      The content on this site is intended for healthcare professionals.


      We use cookies to help provide and enhance our service and tailor content. To update your cookie settings, please visit the Cookie Preference Center for this site.
      Copyright © 2023 Elsevier Inc. except certain content provided by third parties.


      RELX