Research Article| Volume 25, ISSUE 8, P1041-1048, April 15, 1989

Brain morphology and regional cerebral blood flow in anorexia nervosa

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      Cranial computed tomography (CT) was performed in 12 patients with anorexia nervosa, revealing that the majority of the patients displayed ventricular dilatation and/or sulcal widening. In addition, regional cerebral blood flow (rCBF) was measured at admission and once again after weight gain, using xenon-133 dynamic single-photon emission tomography (dSPECT). The mean flow rates assessed at the first examination did not significantly differ from those assessed at the second examination and from those of a control group. There was a significant inverse relationship between the size of the cerebrospinal fluid spaces and the cerebral blood flow in the anorectics; a decrease in ventricular size after weight gain was associated with an increase in cerebral blood flow in this area. This finding, however, has to be interpreted with caution, as partial volume effects render the flow rates ambiguous in brain areas, which, in addition to neuronal tissue, also include ventricular and sulcal structures.
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        • American Psychiatric Association
        ed. 3. Diagnostic and Statistical Manual of Mental Disorders. American Psychiatric Association, Washington, DC1987 (revised)
        • Artmann H
        • Grau H
        • Adelmann M
        • Schleiffer R
        Reversible and non-reversible enlargement of cerebrospinal fluid spaces in anorexia nervosa.
        Neuroradiology. 1985; 27: 304-312
        • Bonte FJ
        • Stokely EM
        Single-photon tomography study of regional cerebral blood flow after stroke: Concise communication.
        J Nucl Med. 1981; 22: 1049-1053
        • Buell U
        • Moser EA
        • Kirsch CM
        • Schmiedek P
        133-Xe-DSPECT (dynamische single photon emissions CT).
        Fortschr Röntgenstr. 1983; 139: 351-358
        • Buell U
        • Moser EA
        • Schmiedek P
        • Leinsinger G
        • Kreisig T
        • Kirsch CM
        • Einhäupl K
        Dynamic SPECT with Xe-133: Regional cerebral blood flow in patients with unilateral cerebrovascular disease: Concise communication.
        J Nucl Med. 1984; 25: 441-446
        • Celsis P
        • Goldman T
        • Henriksen L
        • Lassen NA
        A method for calculating regional cerebral blood flow from emission computed tomography of inert gas concentrations.
        J Comput Assist Tomogr. 1981; 5: 641-645
        • Datlof S
        • Coleman PD
        • Forbes GB
        • Kreipe RE
        Ventricular dilatation on CAT scans of patients with anorexia nervosa.
        Am J Psychiatr. 1986; 143: 96-98
        • Enzmann DR
        • Lane B
        Cranial computed tomography findings in anorexia nervosa.
        J Comput Assist Tomogr. 1977; 1: 410-414
        • Feighner JP
        • Robins E
        • Guze SB
        • Woodruff RA
        • Winokur G
        • Munoz R
        Diagnostic criteria for use in psychiatric research.
        Arch Gen Psychiatry. 1972; 26: 57-63
        • Fox CF
        Neuropsychological correlates of anorexia nervosa.
        Int J Psychiatry Med. 1981; 11: 285-290
        • Gagel O
        Die Erkrankungendes vegetativen Systems.
        in: Handbuch der Inneren Medizin. Springer, Berlin1953: 885-888 (Fünfter Band)
        • Hamsher KdS
        • Halmi KA
        • Benton AL
        Prediction of outcome in anorexia nervosa from neuropsychological status.
        Psychiatry Res. 1981; 4: 79-88
        • Heidrich R
        • Schmidt-Matthias H
        Encephalographische Befunde bei Anorexia nervosa.
        Arch Psychiatr Nervenkr. 1961; 202: 183-201
        • Herholz K
        • Krieg JC
        • Emrich HM
        • Pawlik G
        • Beil C
        • Pirke KM
        • Pahl JJ
        • Wagner R
        • Wienhard K
        • Ploog D
        • Heiss WD
        Regional cerebral glucose metabolism in anorexia nervosa measured by positron emission tomography.
        Biol Psychiatry. 1987; 22: 43-51
        • Kanno I
        • Lassen NA
        Two methods for calculating regional cerebral blood flow from emission computed tomography of inert gas concentrations.
        J Comput Assist Tomogr. 1979; 3: 71-76
        • Kohlmeyer K
        • Lehmkul G
        • Poutska F
        Computed tomography of anorexia nervosa.
        AJNR. 1983; 4: 437-438
        • Krieg JC
        • Backmund H
        • Pirke KM
        Cranial computed tomography findings in bulimia.
        Acta Psychiatr Scand. 1987; 75: 144-149
        • Krieg JC
        • Pirke KM
        • Lauer C
        • Backmund H
        Endocrine, metabolic and cranial computed tomographic findings in anorexia nervosa.
        Biol Psychiatry. 1988; 23: 377-387
        • Krieg JC
        • Lauer C
        • Pirke KM
        Structural brain abnormalities in patients with bulimia nervosa.
        Psychiatry Res. 1989; (in press).
        • Lankenau H
        • Swigar ME
        • Bhimani S
        • Luchins D
        • Quilan DM
        Cranial CT scans in eating disorder patients and controls.
        Compr Psychiatry. 1985; 26: 136-147
        • Lassen NA
        • Henriksen L
        • Paulson O
        Regional cerebral blood flow in stroke by 133-xenon inhalation and emission tomography.
        Stroke. 1981; 12: 284-288
        • Martin F
        Pathologie des aspects neurologiques et psychiatriques de quelques manifestations carentielles avec troubles digestifs et neuro-endocriniens.
        Acta Neurol Belg. 1958; 58: 816-830
        • Maxwell JK
        • Tucker DM
        • Townes BD
        Asymmetric cognitive function in anorexia nervosa.
        Int J Neurosci. 1984; 24: 37-44
        • McKay SE
        • Humphries LL
        • Allen ME
        • Clawson DR
        Neuropsychological test performance of bulimic patients.
        Int J Neurosci. 1986; 30: 73-80
        • Metropolitan Life Insurance Co.
        Statistical Bulletin of the Metropolitan Life Insurance Co. 1959; 40: 1-17
        • Ploog D
        • Pirke KM
        Psychobiology of anorexia nervosa.
        Psychol Med. 1987; 17: 843-859
        • Schmauss C
        • Krieg JC
        Enlargement of cerebrospinal fluid spaces in long-term benzodiazepine abusers.
        Psychol Med. 1987; 17: 869-873
        • Shirahata N
        • Henriksen L
        • Vorstrup S
        • Holm S
        • Lauritzen M
        • Paulson OB
        • Lassen NA
        Regional cerebral blood flow assessed by 133-Xe inhalation and emission tomography: Normal values.
        J Comput Assist Tomogr. 1985; 9: 861-866
        • Stokely EM
        • Sveinsdottir E
        • Lassen NA
        • Rommer P
        A single photon dynamic computer assisted tomograph (DCAT) for imaging brain function in multiple cross sections.
        J Comput Assist Tomogr. 1980; 4: 230-240
        • Witt ED
        • Ryan C
        • Hsu LKG
        Learning deficits in adolescents with anorexia nervosa.
        J Nerv Ment Dis. 1985; 173: 182-184