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Abstract
The Dexamethasone Suppression Test (DST) was administered to 12 patients with major
depression and 4 normal controls. Peripheral blood smears were collected before and
after the DST, and atypical lymphocytes were counted. Six patients who were nonsuppressors
on the DST had a high percentage of so-called stress lymphocytes (Downey type II atypical
lymphocytes). Five of six subjects with normal suppressor responses had low stress
lymphocyte counts or no such cells (p < 0.01). The findings suggest that the stress lymphocyte response might be related to nonsuppression
on the DST in major depression.
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Article info
Publication history
Received in revised form:
October 11,
1988
Received:
May 27,
1986
Footnotes
☆Supported in part by the Pharmacopsychiatric Research Foundation.
Identification
Copyright
© 1989 Published by Elsevier Inc.
