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Abstract
A regional analysis of brain amine and acid metabolite levels was conducted after
chronic administration of the antidepressant tranylcypromine (0.5 mg/kg/day), of a
novel fluorinated analog of this compound, and of clorgyline (1.0 mg/kg/day). These
compounds were administered to male Sprague-Dawley rats for 28 days by subcutaneous
infusion using osmotic minipumps (Alzet 2002). Levels of noradrenaline, 5-hydroxytryptamine,
dopamine, and of the acid metabolites 5-hydroxyindole-3-acetic acid, 3,4-dihydroxyphenylacetic
acid, and homovanillic acid were measured in the frontal cortex, nucleus accumbens,
caudate nucleus, hippocampus, and hypothalamus. After 28 days of drug administration,
sustained increases in amines and decreases in their acid metabolites were observed.
Regional differences in these effects were minimal. These results are consistent with
reports of sustained increases in brain amine concentrations following prolonged administration
of other monoamine oxidase inhibitors.
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References
- Rat brain concentrations of 5-hydroxy-tryptamine following acute and chronic administration of MAO-inhibiting antidepressants.Progr Neuro-Psychopharmacol Biol Psychiatry. 1984; 8: 653-656
- Neurobiological basis of antidepressant treatments.in: Dewhurst WG Baker GB Pharmacotherapy of Affective Disorders. New York University Press, New York1985: 512-530
- Modification of serotonergic and noradrenergic neurotransmissions by repeated administration of monoamine oxidase inhibitors.J Pharmacol Exp Ther. 1986; 237: 987-994
- The effects of chronic regimens of clorgyline and pargyline on monoamine metabolism in rat brain.J Neurochem. 1979; 32: 49-55
- 6-Hydroxydopamine pretreatment effects on α- and β-adrenergic receptor adaptation to clorgyline.Naunyn Schmiedeberg Arch Pharmacol. 1985; 329: 158-161
- Neurochemical and neuropharmacological properties of para-fluorotranylcypromine.Cell Mol Neurobiol. 1987; 7: 271-290
- Osmotic mini-pumps: A convenient program for weight adjusted filling concentrations.Brain Res Bull. 1986; 16: 759-761
- A comparison of the neurochemical properties of the stereoisomers of tranylcypromine in the central nervous system.Cell Mol Biol. 1986; 32: 593-599
- Neurochemical changes in rat brain amines after longterm inhibition of monoamine oxidase by alow dose of tranylcypromine.Biol Psychiatry. 1988; 23: 227-236
- Dopamine in the mesolimbic system of the rat brain: Endogenous levels and the effects of drugs on the uptake mechanism and stimulation of adenylate cyclase activity.J Neurochem. 1974; 22: 265-270
- Effects of acute and chronic phenelzine on regional monoamine metabolism in rats and its potentiation by deuterium substitution.Naunyn Schmiedeberg Arch Pharmacol. 1986; 333: 240-245
- The concentration of striatal tyramine and dopamine metabolism in diabetic rats: The effect of insulin administration.Neuroendocrinology. 1987; 45: 267-273
- Analogues of tranylcypromine: comparison of effects on monoamine oxidase in vitro.in: Proc West Pharmacol Soc. 29. 1986: 279-281
- Effects of chronic monoamine oxidase inhibitor treatment on biogenic amine metabolism in rat brain.Neuropharmacology. 1979; 18: 771-776
- Long-term effects of selective MAO inhibitors on MAO activity and amine metabolism.in: Youdim MBH Paykel ES Monoamine Oxidase Inhibitors: The State of the Art. John Wiley and Sons, Chichester, UK1981: 87-102
- Monoamine oxidase.in: Neuromethods: Neurotransmitter Enzymes. Vol 5. Humana Press, Clifton, NJ1986: 235-272
Article info
Publication history
Received in revised form:
July 27,
1988
Received:
March 24,
1988
Footnotes
☆Supported in part by the Alberta Provincial Mental Health Advisory Council (PMHAC) and the Alberta Heritage Foundation for Medical Research. A.J.G. is a Heritage Medical Scholar.
Identification
Copyright
© 1989 Published by Elsevier Inc.
