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A meta-analytic review of flash and pattern reversal visual evoked potential research indicates that elderly demented patients have longer latencies than age-matched control subjects. In the present empirical research, patients with research diagnoses of probable Alzheimer's disease were compared with sex- and age-matched control subjects using latencies of visual evoked potentials (VEP) elicited by flash and pattern reversal. As compared to control subjects, Alzheimer's disease patients showed significantly longer latencies of the VEP elicited by pattern reversal; the flash only marginally distinguished them. These findings are discussed within the context of VEP recording practices, patient selection, sex and age matching of control subjects, and the visual system.
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Received in revised form: October 13, 1988
Received: July 28, 1988
☆Supported in part by the State of California Department of Mental Health Research Program.
☆☆Portions of this material were presented at the 43rd Annual Convention of the Society of Biological Psychiatry, Montreal, Canada, May 1988.
© 1989 Published by Elsevier Inc.