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Research Article| Volume 25, ISSUE 8, P1003-1013, April 15, 1989

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Visual evoked potentials in dementia: A meta-analysis and empirical study of Alzheimer's disease patients

  • V.E Pollock
    Correspondence
    Address reprint requests to Dr. V.E. Pollock, 1934 Hospital Place, Los Angeles, CA 90033.
    Affiliations
    From the Department of Psychiatry and the Behavioral Sciences (V.E.P., L.S.S., M.Z., R.B.S.). and the Department of Neurology (H.C.C., V.H.), University of Southern California, School of Medicine, Los Angeles, CAUSA
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  • L.S Schneider
    Affiliations
    From the Department of Psychiatry and the Behavioral Sciences (V.E.P., L.S.S., M.Z., R.B.S.). and the Department of Neurology (H.C.C., V.H.), University of Southern California, School of Medicine, Los Angeles, CAUSA
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  • H.C Chui
    Affiliations
    From the Department of Psychiatry and the Behavioral Sciences (V.E.P., L.S.S., M.Z., R.B.S.). and the Department of Neurology (H.C.C., V.H.), University of Southern California, School of Medicine, Los Angeles, CAUSA
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  • V Henderson
    Affiliations
    From the Department of Psychiatry and the Behavioral Sciences (V.E.P., L.S.S., M.Z., R.B.S.). and the Department of Neurology (H.C.C., V.H.), University of Southern California, School of Medicine, Los Angeles, CAUSA
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  • M Zemansky
    Affiliations
    From the Department of Psychiatry and the Behavioral Sciences (V.E.P., L.S.S., M.Z., R.B.S.). and the Department of Neurology (H.C.C., V.H.), University of Southern California, School of Medicine, Los Angeles, CAUSA
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  • R.B Sloane
    Affiliations
    From the Department of Psychiatry and the Behavioral Sciences (V.E.P., L.S.S., M.Z., R.B.S.). and the Department of Neurology (H.C.C., V.H.), University of Southern California, School of Medicine, Los Angeles, CAUSA
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      Abstract

      A meta-analytic review of flash and pattern reversal visual evoked potential research indicates that elderly demented patients have longer Math Eq latencies than age-matched control subjects. In the present empirical research, patients with research diagnoses of probable Alzheimer's disease were compared with sex- and age-matched control subjects using Math Eq latencies of visual evoked potentials (VEP) elicited by flash and pattern reversal. As compared to control subjects, Alzheimer's disease patients showed significantly longer Math Eq latencies of the VEP elicited by pattern reversal; the flash Math Eq only marginally distinguished them. These findings are discussed within the context of VEP recording practices, patient selection, sex and age matching of control subjects, and the visual system.
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