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Abstract
Ten unmedicated female inpatients with major depression (DSM-III) and 10 healthy volunteer
women were given an intravenous injection of 0.1 mg fentanyl at 9:00 am and 9:00 pm
on different days. The prolactin secretory response to this opioid agonist was investigated
for 1 h with serial blood sampling. Repeated measures Analysis of Variance yielded
a significant effect offentanyl administration on prolactin secretion (![Math Eq]()
), and there were elevated hormone responses in the evening (p< 0.005). No group difference was seen between healthy volunteers and depressed patients, but
four of the depressives showed the most blunted response, and three of these low responders
committed suicide within I year.
), and there were elevated hormone responses in the evening (p< 0.005). No group difference was seen between healthy volunteers and depressed patients, but
four of the depressives showed the most blunted response, and three of these low responders
committed suicide within I year.To read this article in full you will need to make a payment
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Article Info
Publication History
Received in revised form:
June 23,
1988
Received:
April 8,
1988
Identification
Copyright
© 1989 Published by Elsevier Inc.
