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Abstract
An early-onset, familial form of Alzheimer's disease (AD) has been reported to be
linked to a locus on the long arm of chromosome 21 (21q21). Furthermore, duplications
in the vicinity of this locus involving the β-amyloid gene and the proto-oncogene
ets-2 have been reported in association with AD. The structural gene for Cu,Zn Superoxide
dismutase, SOD-1, is located between the β-amyloid gene and ets-2. For this reason and because SOD-1 is a plausible candidate for a gene that might influence the fluidity of cellular
membranes, we determined whether or not the subtype of AD with increased platelet
membrane fluidity was associated with an increase in Cu,Zn Superoxide dismutase activity.
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Article Info
Publication History
Received in revised form:
July 29,
1988
Received:
May 13,
1988
Footnotes
☆Supported in part by Research Grant MH43261, Alzheimer Disease Research Center Grant AG05133, and Mental Health Clinical Research Center Grant MH3091S.G.S.Z. was the recipient of NIMH Research Scientist Development Award MH00540.
Identification
Copyright
© 1989 Published by Elsevier Inc.