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SOD-1 activity and platelet membrane fluidity in Alzheimer's disease

  • George S. Zubenko
    Correspondence
    Address reprint requests to Dr. George S. Zubenko, Western Psychiatric Institute and Clinic, Room E-1230, 3811 O'Hara Street, Pittsburgh, PA 15213.
    Affiliations
    From the Department of Psychiatry, Western Psychiatric Institute and Clinic, and the Geriatric Health Services, School of Medicine, University of Pittsburgh, Pittsburgh, PAUSA
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  • Pamela Sauer
    Affiliations
    From the Department of Psychiatry, Western Psychiatric Institute and Clinic, and the Geriatric Health Services, School of Medicine, University of Pittsburgh, Pittsburgh, PAUSA
    Search for articles by this author
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      Abstract

      An early-onset, familial form of Alzheimer's disease (AD) has been reported to be linked to a locus on the long arm of chromosome 21 (21q21). Furthermore, duplications in the vicinity of this locus involving the β-amyloid gene and the proto-oncogene ets-2 have been reported in association with AD. The structural gene for Cu,Zn Superoxide dismutase, SOD-1, is located between the β-amyloid gene and ets-2. For this reason and because SOD-1 is a plausible candidate for a gene that might influence the fluidity of cellular membranes, we determined whether or not the subtype of AD with increased platelet membrane fluidity was associated with an increase in Cu,Zn Superoxide dismutase activity.
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