Brief report| Volume 25, ISSUE 5, P626-630, March 01, 1989

Population frequencies of tyrosine hydroxylase restriction fragment length polymorphisms in bipolar affective disorder

  • Richard D. Todd
    Address reprint requests to Dr. Richard D. Todd, Department of Psychiatry, Washington University School of Medicine, 4940 Audubon Avenue, St. Louis, MO 63110.
    From the Department of Psychiatry, Washington University School of Medicine, St. Louis, MOUSA
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  • Karen L. O'Malley
    From the Departments of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MOUSA
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        • Baron M
        • Ris N
        • Hamburger R
        • et al.
        Genetic linkage between X-chromosome markers and bipolar affective illness.
        Nature. 1987; 326: 289-292
        • Bunney Jr, WE
        • Davis JM
        Norepinephrine in depressive reactions.
        Arch Gen Psychiatry. 1965; 13: 483-494
        • Coker III, GT
        • Vinnedge L
        • O'Malley KL
        Characterization of rat and human tyrosine hydroxylase genes: functional expression of both promoters in neuronal and non-neuronal cell types.
        Biochem Biophys Res Comm. 1988; (in press).
        • Coryell W
        • Cloninger CR
        • Reich T
        Clinical assessment: use of non-physician interviewers.
        J Nerv Ment Dis. 1978; 166: 306-599
        • Cox DW
        • Woo SLC
        • Mansfield T
        DNA restriction fragments associated with α1,-antitrypsin indicate a single origin for deficiency allele PIZ.
        Nature. 1985; 316: 79-81
        • Detera-Wadleigh SD
        • Berrettini WH
        • Goldin LR
        • Boorman D
        • Andersen S
        • Gershon ES
        Close linkage of C-Harvey-Ras-I and the insulin gene to affective disorder is ruled out in three North American pedigrees.
        Nature. 1987; 325: 806-808
        • Egeland JA
        • Gerhard DS
        • Pauls DL
        • et al.
        Bipolar affective disorder linked to DNA markers on chromosome II.
        Nature. 1987; 325: 783-787
        • Endicott J
        • Spitzer RL
        Schedule for Affective Disorders and Schizophrenia Lifetime Version (SADS-L).
        Archs Gen Psychiatry. 1978; 35: 837-844
        • Hodgkinson S
        • Sherrington R
        • Gurling H
        • et al.
        Molecular genetic evidence of heterogeneity in manic depression.
        Nature. 1987; 325: 805-806
        • LeBourdellès B
        • Boularand S
        • Boni C
        • Horellou P
        • Dumas S
        • Grima B
        • Mallet J
        Analysis of the 5′ region of the human tyrosine hydroxylase gene: Combination patterns of exon splicing generate multiple regulated tyrosine hydroxylase isoforms.
        J Neurochem. 1988; 50: 988-991
        • Lewis EJ
        • Herrington CA
        • Chikaraishi DM
        Transcriptional regulation of the tyrosine hydroxylase gene by glucocorticoid and cAMP.
        in: Proc Natl Acad Sci USA. 84. 1987: 3550-3554
        • Longmire JL
        • Albright KL
        • Lewis AK
        • Meincke LJ
        • Hildebrand CE
        A rapid and simple method for the isolation of high molecular weight cellular and chromosome specific DNA in solution without the use of organic solvents.
        Nucleic Acids Res. 1987; 15: 859
        • Mendlewicz J
        • Sevy S
        • Brocas B
        • et al.
        Polymorphic DNA marker on X-chromosome and manic depression.
        Lancet. 1987; i: 1230-1232
        • Moss PAH
        • Davis KE
        • Boni C
        • Mallet J
        • Reeders ST
        Linkage of tyrosine hydroxylase to four other markers on the short arm of chromosome II.
        Nucleic Acids Res. 1986; 14: 9927-9932
        • Neitzel H
        A routine method for the establishment of permanent growing lymphoblastoid cell lines.
        Hum Genet. 1986; 73: 320-326
        • O'Malley KL
        • Rotwein P
        Human tyrosine hydroxylase and insulin genes are contiguous on chromosome II.
        Nucleic Acids Res. 1988; 16: 4437-4445
        • O'Malley KL
        • Anhalt MJ
        • Martin BM
        • Kelsoe JR
        • Winfield SL
        • Ginns EI
        Isolation and characterization of the human tyrosine hydroxylase gene: Identification of 5′ alternative splice sites responsible for multiple mRNAs.
        Biochemistry. 1987; 26: 6910-6914
        • Reich T
        • Clayton P
        • Winokur G
        Family history studies: V. The genetics of mania.
        Am J Psychiatry. 1969; 125: 1358-1369
        • Rigby PWJ
        • Dieckman M
        • Rhodes C
        • Berg P
        Labelling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I.
        J Mol Biol. 1977; 113: 237-245
        • Schildkraut JJ
        The catecholamine hypothesis of affective disorders: A review of supporting evidence.
        Am J Psychiatry. 1965; 122: 509-522
        • Wahl G
        • Stern M
        • Stark GR
        Efficient transfer of large DNA fragments from agarose gels to diazobenzloxymethal-paper and rapid hybridization by using dextran sulfate.
        in: Proc Natl Acad Sci USA. 76. 1979: 3683-3687