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In a previous study, bipolar patients were found to be more sensitive than controls to induction of rapid eye movement (REM) sleep by the direct muscarinic agonist arecoline. We have replicated this observation in a new group of patients and controls. However, much overlap between groups was seen. Muscarinic supersensitivity appears to be present in some bipolar affective patients, but the REM induction procedure may not be the optimal method for measuring it.
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Received in revised form: June 27, 1988
Received: December 28, 1987This study was only possible with the assistance of many clinical research professionals. Excellent research nursing on NIMH Wards 3 East and 4 West was essential: the authors thank Betty Curtis, MSN, Ann Montgomery, MA, Sheryl Myers, MSN, and all of the nursing staff on these units. Technical sleep recording expertise was provided by Deborah Garnett, MSW, Helen Stephens, BS, Charles Barker, BA, and others. We are grateful for the assistance of David Jimerson, M.D., Rex Cowdry, M.D., and Thomas Wehr, M.D., in coordinating the study on NIMH wards. Natraj Sitaram, M.D., was generous with his time and experience as a consultant. We also acknowledge excellent statistical assistance from Harry Brittain and Dawn Lawrence.
© 1989 Published by Elsevier Inc.