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Abstract
Auditory evoked potentials were recorded using a paired click, conditioning-testing
paradigm in 10 schizophrenics and in 10 normal subjects with no family history of
psychotic disorder. The paradigm is used to demonstrate central nervous system gating
of responsiveness to auditory stimuli by examining the extent to which the response
to the conditioning stimulus diminishes the response to a test stimulus occurring
a short time later. Recordings were made at conditioning-testing intervals of 500
msec, 150 msec, and 75 msec to determine subjects' gating of responsiveness to stimuli
repeated at various intervals. The schizophrenics had conditioning-testing ratios
indicative of poor gating of the auditory P50 wave at the 500-msec and 150-msec intervals,
but most patients had good sensory gating at the 75-msec interval. Normal subjects
showed good sensory gating at all three intervals. Results suggest that although sensory
gating mechanisms responsible for changes in neuronal response at longer intervals
are chronically defective in schizophrenics, other gating mechanisms functioning at
shorter intervals appear to be intact and function well in most patients. The results
may lead to increased specification of the neurobiological basis of sensory abnormalities
in schizophrenia.
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Article info
Publication history
Received in revised form:
May 16,
1988
Received:
October 27,
1987
Footnotes
☆Supported by USPHS Grants MH-38321 and RR-00051 and the VA Medical Research Service.
Identification
Copyright
© 1989 Published by Elsevier Inc.
