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Abstract
We have recently shown that electroencephalogram (EEG) coherence data recorded with
common reference methods, including those obtained from schizophrenics, are confounded
by power and phase effects. Three published reports using bipolar recordings found
that EEG coherence was higher in schizophrenics; however, only medicated patient s
were studied. To extend these findings, we measured EEG coherence from bipolar EEG
recordings in unmedicated schizophrenics (n = 10), affective disorder patients (n = 8), and normal controls (n = 13) during resting and task conditions. Seven schizophrenics were restudied after
a period of neuroleptic treatment. Schizophrenics had higher acrosstask interhemispheric
(p < 0.05) and intrahemispheric (p < 0.04) coherence in the theta band and tended to have higher intrahemispheric alpha coherence(p < 0.08). Medication treatment was associated with clinical improvement and increases in spectral
power, but not with changes in coherence values. These results confirm those obtained by
earlier investigations and suggest that increased coherence reflects the presence
of anomalous cortical organization in schizophrenics rather than medication effects
or transient states related to acute clinical disturbance.
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References
- A coordination of hand preference and skill replicated.Br J Psychology. 1976; 67: 587-592
- Asymmetry in EEG alpha coherence and power: Effects of task and sex.Electroencephalogr Clin Neurophysiol. 1978; 45: 393-401
- EEG correlates of visual-motor practice in man.Electroencephalogr Clin Neurophysiol. 1975; 38: 415-422
- Applied Multiple Regression/Correlation Analysis for the Behavioral Sciences.2nd ed. Lawrence Erlbaum Associates, Hillsdale, NJ1983
- Comparative doses and costs of antipsychotic medication.Arch Gen Psychiatry. 1976; 33: 858-861
- Common reference coherence data are confounded by power and phase effects.Electrocephalogr Clin Neurophysiol. 1988; (in press).
- Schizophrenia: Caused by a fault in programmed synaptic elimination during adolescence?.J Psychiatr Res. 1983; 17: 319-334
- Statistical quantitative EEG studies of depression, mania, schizophrenia and normals.Biol Psychol. 1984; 19: 257-279
- EEG coherence and power in the discrimination of psychiatric disorders and medication effects.Biol Psychiatry. 1986; 21: 1175-1188
- EEG coherence and power changes during a continuous movement task.Int J Psychophysiology. 1986; 4: 99-110
- Spatial organization of the EEG in normal and schizophrenic subjects.Electromyogr Clin Neurophysiol. 1979; 19: 125-145
- Mental activity and the EEG: Task and workload related effects.Med and Biol Eng and Comput. 1981; 19: 185-194
- Electrical Fields of the Brain: The Neurophysics of EEG.Oxford University Press, New York1981
- An introduction to the coherence function and its use in EEG signal analysis.J Med Eng Technol. 1981; 5: 279-288
- A comparison of schizophrenic and neurotic patients using EEG power and coherence spectra.in: Gruzelier J Flor-Henry P Hemisphere Asymmetries of Function in Psychopathology. Elsevier/ North-Holland Biomedical Press, Amsterdam1979: 257-292
- EEG coherence, lateral preference and schizophrenia.Psychol Med. 1983; 13: 299-306
- Schedule for Affective Disorders and Schizophrenia.3rd ed. Biometrics Research, New York State Psychiatric Institute, New York1978
- Schedule for Affective Disorders and Schizophrenia, Life-time Version.3rd ed. Biometrics Research, New York State Psychiatric Institute, New York1978
- Regional changes in EEG power and coherence during cognition: Intensive study of two individuals.Behav Neurosci. 1985; 99: 564-577
- Electroencephalographic coherence in schizophrenia: A preliminary study.in: Gruzelier J Flor-Henry P Hemisphere Asymmetries of Function in Psychopathology. Elscvier/North-Holland Biomedical Press, Amsterdam1979: 285-292
Article info
Publication history
Received in revised form:
February 4,
1988
Received:
May 7,
1987
Footnotes
☆Supported in part by the Veterans Administration Merit Review Medical Research Program.
Identification
Copyright
© 1989 Published by Elsevier Inc.
