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Abstract
Daytime melatonin was measured by radioimmunoassay in 113 depressed outpatients before
and after treatment with imipramine, mianserin, phenelzine, and placebo. At baseline,
elevation of daytime melatonin values above expected levels suggests nonspecificity
of the assay. After 6 weeks of treatment, melatonin levels were somewhat lower in
patients on imipramine, mianserin, and placebo and slightly increased in patients
treated with phenelzine. Changes in melatonin levels during treatment were significantly
different for phenelzine compared with the other treatments. These findings are consistent
with alterations in β-adrenergic functioning or changes in serotonin levels.
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Article info
Publication history
Received in revised form:
March 4,
1988
Received:
October 29,
1987
Identification
Copyright
© 1989 Published by Elsevier Inc.
