Advertisement
Research Article| Volume 26, ISSUE 6, P576-580, October 1989

ADH secretion in schizophrenic patients on antipsychotic drugs

DOI:https://doi.org/10.1016/0006-3223(89)90082-6
ADH secretion in schizophrenic patients on antipsychotic drugs
Previous ArticleRelationships between brain ct scan findings and cortisol in psychotic and nonpsychotic depressed patients
Next ArticleLymphocyte subpopulations in depressed elderly women
      This paper is only available as a PDF. To read, Please Download here.

      Abstract

      The authors studied antidiuretic hormone (ADH) secretion in schizophrenics on antipsychotic drugs. The mean plasma level of ADH is lower among schizophrenics than among controls at comparable values of plasma osmolality. In regression analysis of the relationship between plasma ADH and plasma osmolality, the slope of the regression line is gentler and the threshold of ADH secretion is lower in schizophrenics than that in control subjects. The authors suggest that the relationship between plasma ADH and plasma osmolality may be different in schizophrenics receiving antipsychotic drugs than in controls.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Biological Psychiatry
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Register: Create an account
      Institutional Access: Sign in to ScienceDirect

      References

        • Goldman MB
        • Luchins DJ
        • Robertson GL
        Mechanism of altered water metabolism in psychotic patients with polydipsia and hyponatremia.
        N Engl J Med. 1988; 318: 397-403
        • Raskind MA
        • Orenstein H
        • Graham CT
        Acute psychosis, increased water ingestion, and inappropriate antidiuretic hormone secretion.
        Am J Psychiatry. 1975; 132: 907-910
        • Reichlin S
        Neuroendocrinology.
        in: Williams WH Textbook of Endocrinology. H. W. B. Saunders Company, Philadelphia1981: 589-645
        • Robertson GL
        • Shelton RL
        • Athar S
        The osmoregulation of vasopressin.
        Kid Int. 1976; 10: 25-37
        • Vorwieg WVR
        • Rowe WT
        • David JJ
        • Spradlin WW
        Hypostheuria as a marker for selfinduced water intoxication and schizophrenic disorders.
        Am J Psychiatry. 1984; 141: 1258-1260
        • Vorwieg WVR
        • Rowe WT
        • David JJ
        • Sutker LH
        • Spradlin JJ
        Evaluation of patients with self-induced water intoxication and schizophrenic disorders (SIWIS).
        J Nerv Ment Dis. 1984; 172: 552-555
        • Weitzman R
        • Shelton RL
        • Athar S
        Water metabolism and the neurohypophysial hormones.
        in: Bondy PK Rosenberg LE Metabolic Control and Disease. H. W. B. Saunders Company, Philadelphia1980: 1241-1323

      Article info

      Publication history

      Received in revised form: January 6, 1989
      Received: June 8, 1988

      Identification

      DOI: https://doi.org/10.1016/0006-3223(89)90082-6

      Copyright

      © 1989 Published by Elsevier Inc.

      ScienceDirect

      Access this article on ScienceDirect
      We use cookies to help provide and enhance our service and tailor content. To update your cookie settings, please visit the for this site.
      Copyright © 2023 Elsevier Inc. except certain content provided by third parties. The content on this site is intended for healthcare professionals.


      RELX