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Abstract
Calcium metabolism has been reported to be disturbed in some forms of affective disorder.
We studied concurrently a battery of calcium measures in 29 unipolar, 14 bipolar depressed,
11 manic, and 10 healthy control subjects. In addition to measures of extracellular
calcium, we studied intracellular calcium concentration in platelets and measures
that reflect cellular capability to maintain a low intracellular Ca++ concentration in red blood cells (RBCs) and platelets. Plasma calcium was lower in
unipolar and manic patients than in control subjects. Platelet calcium concentration
was lower in unipolar than bipolar depressed patients. RBC Ca++ adenosine triphosphatase (ATPase) was lower in unipolar and control subjects than
in bipolar depressed and manic patients. Platelet Ca++ ATPase and Ca++ uptake were inversely correlated with severity of illness in unipolar patients. In
bipolar depressed patients, RBC Ca++ ATPase and platelet Ca++ uptake were inversely correlated with severity. In addition to indicating abnormalities
in calcium activity in affective disorders, the data suggest that unipolar and bipolar
patients differ in several measures and may have different pathophysiological disturbances
in calcium metabolism.
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© 1988 Published by Elsevier Inc.
