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Abstract
Children with attention deficit disorder with hyperactivity were treated with methylphenidate
HCl (0.74 ± 0.2 mg/kg/day) for 2 weeks in an open trial to assess changes in the urinary excretion of catecholamines
and behavior. The purpose of this study was to confirm earlier work that methylphenidate
has a distinctly different effect on urinary 3-methoxy-4-hydroxyphenylgfycol (MHPG)
excretion as compared to earlier studies with dextroamphetamine. Results confirmed
the earlier finding that methylphenidate does not significantly change urinary MHPG
excretion. No significant relationship was found between behavioral change and any
of the urinary catecholamines or metabolites measured.
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Article info
Publication history
Received in revised form:
May 8,
1987
Received:
January 8,
1987
Identification
Copyright
© 1988 Published by Elsevier Inc.
