This paper is only available as a PDF. To read, Please Download here.
Children with attention deficit disorder with hyperactivity were treated with methylphenidate HCl (0.74 ± 0.2 mg/kg/day) for 2 weeks in an open trial to assess changes in the urinary excretion of catecholamines and behavior. The purpose of this study was to confirm earlier work that methylphenidate has a distinctly different effect on urinary 3-methoxy-4-hydroxyphenylgfycol (MHPG) excretion as compared to earlier studies with dextroamphetamine. Results confirmed the earlier finding that methylphenidate does not significantly change urinary MHPG excretion. No significant relationship was found between behavioral change and any of the urinary catecholamines or metabolites measured.
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Biological Psychiatry
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
- A review of stimulant drug research with hyperactive children.J Child Psychol Psychiatry. 1977; 18: 137-165
- Urinary 3-methoxy-4-hydroxyphenylglycol and homovanillic acid response to D-amphetamine in hyperactive children.Biol Psychiatry. 1981; 16: 779-787
- A teacher rating scale for use in drug studies with children.Am J Psychiatry. 1969; 126: 152-156
- Rating scales for use in drug studies with children.Psychopharmacol Bull. 1973; : 59-60
- Treatment of childhood hyperactivity with desipramine: Plasma drug concentration, cardiovascular effects, plasma and urinary catecholamines and clinical response.Clin Pharmacol Ther. 1986; 39: 72-81
- Endogenous creatinine in serum and urine.in: Proc Soc Exp Biol Med. 74. 1950: 148-151
- Urinary catecholamine and amphetamine excretion in hyperative and normal boys.J Nerv Ment Dis. 1978; 166: 731-737
- Urinary catecholamine metabolites in hyperkinetic boys treated with D-amphetamine.Am J Psychiatry. 1977; 134: 1276-1279
- Urinary MHPG excretion in minimal brain dysfunction and its modification by D-amphetamine.Am J Psychiatry. 1979; 136: 667-671
- Urinary MHPG and HVA excretion in boys with attention deficit disorder and hyperactivity treated with d-amphetamine.Biol Psychiatry. 1983; 18: 707-714
- Urinary monoamine metabolites in children with minimal brain dysfunction.Am J Psychiatry. 1971; 127: 1411-1415
- Conners teacher rating scale for use in drug studies with children: An empirical study.J Abnorm Child Psychol. 1975; 3: 217-229
- An improved method for determination of plasma norepinephrine.Biomed Mass Spectrum. 1980; 7: 396-398
- Urinary 3-methoxy-4-hydroxyphenylglycol sulfate excretion in seventy-three school children with minimal brain dysfunction syndrome.Biol Psychiatry. 1984; 19: 861-870
- Stimulants, urinary catecholamines and indoleamines in hyperactivity: A comparison of methylphenidate and dextroamphetamine.Arch Gen Psychiatry. 1985; 42: 251-255
- Treatment of hyperactive children with monoamine oxidase inhibitors: II. Plasma and urinary monoamine findings after treatment.Arch Gen Psychiatry. 1985; 42: 969-973
- Pemoline and urinary excretion of catecholamines and indoleamines in children with attention deficit disorder.Am J Psychiatry. 1986; 143: 359-362
Received in revised form: May 8, 1987
Received: January 8, 1987
© 1988 Published by Elsevier Inc.