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Abstract
We quantified the amounts of salivary prostaglandin (PG) D2, PGE2, and PGF2α by radioimmunoassay in 32 patients with major depressive disorder, 16 patients with
minor depressive disorder, 24 patients with neurotic disorders (panic, generalized
anxiety, phobic, somatization, and obsessive compulsive), and 28 healthy controls.
In the saliva of patients with major depressive disorder, the concentrations of immunoreactive
PCs (PGD2, 385 ± 71 pg/ml; PGE2, 498 ± 105 pg/ml; PGF2α, 444 ± 100 pg/ml) were significantly higher than those of the healthy controls (PGD2, 129 ± 18 pg/ml; PGE2, 207 ± 25 pg/ml; PGF2α, 164 ± 17 pg/ml). On the other hand, the salivary concentrations of immunoreactive PCs from patients
with minor depressive disorder or neurotic disorders were comparable to those of the
controls. These results suggest that the level of salivary PCs may be an indicator
of major depressive disorder.
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Article info
Publication history
Received in revised form:
June 13,
1987
Received:
January 13,
1987
The authors wish to thank Y. Imai, M.D., Ph.D., the director of the 1st Department of Physiology of Osaka Medical College, for many important suggestions; Dr.H. Hayashi, Hayaishi Bioinformation Transfer Project, for the supply of specific antiserum for PGD2; and Ono Pharmaceuticals, Osaka, for the supply of prostaglandin standards.Identification
Copyright
© 1988 Published by Elsevier Inc.
