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Correspondence| Volume 24, ISSUE 6, P721-723, October 1988

One-carbon cycle metabolism in obsessive-compulsive disorder

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      References

        • Alarcon RD
        • Tolbert LC
        • Monti JA
        • et al.
        One-carbon metabolism disturbances in affective disorders.
        J Affect Dis. 1985; 9: 297-301
        • Baldessarini RJ
        Neuropharmacology of s-adenosyl-l-methionine. Am J Med 83(supply 5A):95–103. Carney MWP, Toone BK, Reynolds EH (1987): s-Adenosylmethionine and affective disorder.
        Am J Med. 1987; 83: 104-106
        • Hirschfeld RMA
        • Cross CK
        Epidemiology of affective disorders.
        Arch Gen Psychiatry. 1982; 39: 35-46
        • Kelsoe Jr, JR
        • Tolbert LC
        • Crews EL
        • et al.
        Kinetic evidence for decreased methionine adenosyltransferase activity in erythrocytes from schizophrenics.
        J Neurosci Res. 1982; 8: 99-103
        • Morere DA
        • Alarcon RD
        • Monti JA
        • et al.
        Medication effects on one-carbon metabolism in schizophrenia, mania, and major depression.
        J Clin Psychopharmacol. 1986; 6: 155-160
        • Smythies JR
        • Alarcon RD
        • Bancroft JA
        • et al.
        Role of the one-carbon cycle in neuropsychiatry.
        in: Biological Methylation and Drug Design. Borchardt RT, Creveling CR, Ueland PM. Humana Press, Clifton, NJ1986: 351-362
        • Smythies JR
        • Alarcon RD
        • Morere D
        • et al.
        Abnormalities of one-carbon metabolism in psychiatric disorders: Study of methionine adenosyltransferase kinetics and lipid composition of erythrocyte membranes.
        Biol Psychiatry. 1986; 21: 1391-1398
        • Tolbert LC
        • Monti JA
        • O'Shields H
        • et al.
        Defects in transmethylation and membrane lipids in schizophrenia.
        Psychopharmacol Bull. 1983; 19: 594-599
        • Tolbert LC
        • Monti JA
        • Walter-Ryan WG
        Clinical correlations of one-carbon metabolism abnormalities.
        Prog Neuro-Psychopharmacol Biol Psychiatry. 1988; (in press)
        • Zohar J
        • Insel TR
        Obsessive-compulsive disorder: Psychobiological approaches to diagnosis, treatment, and pathophysiology.
        Biol Psychiatry. 1987; 22: 667-687