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The effect of theophylline (5, 15, or 30 mg/kg sc) on the catalepsy induced by haloperidol in the rat was studied. Theophylline was shown to induce a dose-dependent inhibition of this catalepsy. These data support the hypothesis that the methylxanthines are dopamine agonists and suggest that coffee, tea, and cola drinks should be avoided by patients undergoing neuroleptic treatment.
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Received in revised form: January 19, 1988
Received: October 5, 1987We wish to acknowledge the excellent technical assistance given by A. Rubio and S. Lopez.
☆Supported in part by grants from Ferrer International, S.A., 1986.
© 1988 Published by Elsevier Inc.