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Research Article| Volume 24, ISSUE 6, P642-648, October 1988

Theophylline reverses haloperidol-induced catalepsy in the rat possible relevance to the pharmacological treatment of psychosis

  • Miquel Casas
    Correspondence
    Address reprint requests to Dr. M. Casas, Laboratori de Neuropsicofarmacologia, Hospital de S. Pau, Facultat de Medicina, Avda. S. Antoni Ma. Claret 167, 08025, Barcelona, Spain.
    Affiliations
    From the Laboratori de Neuropsicofarmacologia, Fundació d'Investigació de la Santa Creu i Sant Pau, Hospital de S. Pau (Medical School, U.A.B.), Barcelona, Spain
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  • Sergi Ferre
    Affiliations
    From the Laboratori de Neuropsicofarmacologia, Fundació d'Investigació de la Santa Creu i Sant Pau, Hospital de S. Pau (Medical School, U.A.B.), Barcelona, Spain
    Search for articles by this author
  • Teresa Guix
    Affiliations
    From the Laboratori de Neuropsicofarmacologia, Fundació d'Investigació de la Santa Creu i Sant Pau, Hospital de S. Pau (Medical School, U.A.B.), Barcelona, Spain
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  • Francesc Jane
    Affiliations
    From the Laboratori de Neuropsicofarmacologia, Fundació d'Investigació de la Santa Creu i Sant Pau, Hospital de S. Pau (Medical School, U.A.B.), Barcelona, Spain
    Search for articles by this author
DOI:https://doi.org/10.1016/0006-3223(88)90138-2
Theophylline reverses haloperidol-induced catalepsy in the rat possible relevance to the pharmacological treatment of psychosis
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      Abstract

      The effect of theophylline (5, 15, or 30 mg/kg sc) on the catalepsy induced by haloperidol in the rat was studied. Theophylline was shown to induce a dose-dependent inhibition of this catalepsy. These data support the hypothesis that the methylxanthines are dopamine agonists and suggest that coffee, tea, and cola drinks should be avoided by patients undergoing neuroleptic treatment.
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      Article info

      Publication history

      Received in revised form: January 19, 1988
      Received: October 5, 1987
      We wish to acknowledge the excellent technical assistance given by A. Rubio and S. Lopez.

      Footnotes

      ☆Supported in part by grants from Ferrer International, S.A., 1986.

      Identification

      DOI: https://doi.org/10.1016/0006-3223(88)90138-2

      Copyright

      © 1988 Published by Elsevier Inc.

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