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Abstract
In order to test the hypothesis that changes in the hypothalamic-pituitary axis during
sleep deprivation are related to the antidepressant effects of this procedure, we
measured thyroid-stimulating hormone (TSH) and prolactin levels in 32 depressed patients
at 2:00 am during a night before, during, and after total sleep deprivation (TSD).
TSH levels increased significantly (p < 0.05) during TSD, and prolactin levels decreased significantly (p < 0.0001). When we divided the patients into responder and nonresponder groups based on a 30%
reduction in the Hamilton Rating Scale, there was no difference between the two groups
in their hormone levels on the baseline, TSD, or recovery nights. Changes in prolactin
or TSH were not correlated with clinical improvement when the two groups were considered
together or in the responder/ nonresponder groups separately. Baseline values of both
hormones were significantly (p < 0.01) correlated with their respective levels during TSD and recovery sleep. These findings
indicate that the relative levels of nocturnal TSH and prolactin are stable even within
acutely depressed individuals and that changes in their levels are not related to
the clinical response to sleep deprivation.
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Article info
Publication history
Received in revised form:
December 21,
1987
Received:
June 30,
1987
Footnotes
☆Supported by the German Research Foundation (DFG) (S.K.).
Identification
Copyright
© 1988 Published by Elsevier Inc.
