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Abstract
Monoamine oxidase (MAO) in blood platelets has been used as a model to study MAO in
the central nervous system, where disorders in serotonergic systems are thought to
occur in depression. Inconsistent changes in platelet MAO of depressed patients have
been reported when several substrates other than serotonin (5-HT) have been used.
To correlate changes in platelet MAO activity with the enzyme activity in central
serotonergic systems, the platelet MAO activity of depressed patients (first unmedicated
and then after 3 weeks and 2 months of imipramine treatment) and normal controls was
measured using 5-HT as substrate. The results showed that there is a steady, measurable
platelet MAO activity with that substrate. This activity was significantly higher
in unmedicated depressed patients than in controls, and it decreased progressively
with imipramine treatment, reaching a normal level when the patients were clinically
recovered from depression after 2 months of therapy.
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Article info
Publication history
Received in revised form:
March 23,
1987
Received:
August 25,
1986
Identification
Copyright
© 1988 Published by Elsevier Inc.
