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Abstract
Six patients [5 men and I woman, mean age 37.3 ± 8.2 (SD) years] with psychosis, intermittent
hyponatremia, and polydipsia (PIP syndrome) underwent a sequence of treatments in
an effort to normalize basal serum sodium levels and thereby protect the patients
against complications, including hyponatremic seizures and coma. The morning baseline
group mean basal serum sodium value was 132.5 ± 3.8 meqlliter. Over a 20-monthperiod,
the sequence of treatments was salt-added diet, lithium and phenytoin, and lithium
alone. Each treatment program yielded morning group mean basal serum sodium determinations
superior to baseline values, except for the program of lithium alone, which could
not be tolerated. The combination of lithium and phenytoin provided a morning group
mean basal serum sodium level of 140.6 ±3.2 meqlliter, which was superior (p < 0.01) to all other treatment modalities. Early morning hyposthenuria persisted throughout
the 20-month period of observation.
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Article info
Publication history
Received in revised form:
April 11,
1987
Received:
February 27,
1987
Identification
Copyright
© 1988 Published by Elsevier Inc.
