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The authors used a thermoregulation paradigm to evaluate effects of amitriptyline (AMI) on the sensitivity of a nicotinic mechanism involved in the regulation of core temperature in rats. Treatment with this tricyclic was associated with a significant increase in the hypothermie response to nicotine. Supersensitivity persisted for a minimum of 7.5 days following the last dose of AMI, and a significant proportion of animals displayed increased sensitivity after 14.5 days of abstinence. Implications for the mechanism of action of AMI are highlighted.
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Received in revised form: February 27, 1987
Received: September 15, 1986
☆Presented at the Annual Meeting of the American College of Neuropsychopharmacology, Washington, D.C., December 8–12, 1986.
☆☆Supported in part by Physician Scientist Development Award Grant MH00553-02 (SCD).
© 1988 Published by Elsevier Inc.