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Abstract
The authors used a thermoregulation paradigm to evaluate effects of amitriptyline
(AMI) on the sensitivity of a nicotinic mechanism involved in the regulation of core
temperature in rats. Treatment with this tricyclic was associated with a significant
increase in the hypothermie response to nicotine. Supersensitivity persisted for a
minimum of 7.5 days following the last dose of AMI, and a significant proportion of
animals displayed increased sensitivity after 14.5 days of abstinence. Implications
for the mechanism of action of AMI are highlighted.
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References
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Article info
Publication history
Received in revised form:
February 27,
1987
Received:
September 15,
1986
Footnotes
☆Presented at the Annual Meeting of the American College of Neuropsychopharmacology, Washington, D.C., December 8–12, 1986.
☆☆Supported in part by Physician Scientist Development Award Grant MH00553-02 (SCD).
Identification
Copyright
© 1988 Published by Elsevier Inc.
