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Abstract
The purpose of this article is to document that ketamine hydrochloride, administered
at an anesthetic dosage of about 100 mg/kg, produces tongue contractile activity in
the rat. The methods for monitoring and quantitating ketamine-induced tongue contractions
(KITCs) are described. We also found that neuroleptic agents consistently and readily
abolish KITCs. On the basis of these observations and other pharmacological properties
of ketamine, we propose that KITCs may be a useful model for studying neuroleptic-induced
oral dyskinesia, e.g., tardive dyskinesia. Additional findings in support of this
model are presented.
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Article info
Publication history
Received in revised form:
March 26,
1987
Received:
January 30,
1987
Footnotes
☆Supported in part by funds from Merck, Sharp, and Dohme, the Upjohn Company, Mead Johnson, Lederle Laboratories, SKF Laboratories, and Roche Laboratories.
Identification
Copyright
© 1988 Published by Elsevier Inc.
