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Abstract
This prospective study included 32 patients with primary hyperparathyroidism (HPT).
As compared with a healthy reference group, the patients had pronounced psychiatric
symptomatology [CPRS score 17.2 ± 9.0 (SD) versus 4.4 ± 2.0], which was mainly affective
in character. The severity of symptoms was not related to the serum calcium or parathyroid
hormone concentrations. The majority of the patients had low CSF concentrations of
monoamine metabolites (5-HIAA, HVA, and MHPG) and, in particular, those with the most
severe psychiatric symptoms had low values for 5-HIAA. At follow-up, 1 year after
parathyroid surgery, the patients displayed a clear improvement in mental health (CPRS
score 4.4 ± 3.0) together with an increase in CSF concentrations of 5-HIAA and HVA.
The study demonstrates that significant psychiatric disturbances, which can be improved/normalized
by surgery, are common in patients with HPT and are possibly related to changes in
the central nervous system turnover of monoamines.
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Article info
Publication history
Received in revised form:
April 13,
1987
Received:
November 26,
1986
Footnotes
☆Supported by a grant from Fredrik and Ingrid Thurings Foundation, Stockholm, and the Swedish Medical Research Council.
Identification
Copyright
© 1988 Published by Elsevier Inc.
