This paper is only available as a PDF. To read, Please Download here.
This prospective study included 32 patients with primary hyperparathyroidism (HPT). As compared with a healthy reference group, the patients had pronounced psychiatric symptomatology [CPRS score 17.2 ± 9.0 (SD) versus 4.4 ± 2.0], which was mainly affective in character. The severity of symptoms was not related to the serum calcium or parathyroid hormone concentrations. The majority of the patients had low CSF concentrations of monoamine metabolites (5-HIAA, HVA, and MHPG) and, in particular, those with the most severe psychiatric symptoms had low values for 5-HIAA. At follow-up, 1 year after parathyroid surgery, the patients displayed a clear improvement in mental health (CPRS score 4.4 ± 3.0) together with an increase in CSF concentrations of 5-HIAA and HVA. The study demonstrates that significant psychiatric disturbances, which can be improved/normalized by surgery, are common in patients with HPT and are possibly related to changes in the central nervous system turnover of monoamines.
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Biological Psychiatry
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
- Hyperparathyroidism and paranoid psychosis. Case report and review of the literature.Br J Psychiatry. 1984; 145: 477
- Interacting neurotransmitter systems. A non-experimental approach to the 5HIAA-HVA correlation in human CSF.J Psychiatr Res. 1986; 20: 175
- Magnesium and mental illness.Compr Psychiatry. 1979; 20: 47
- Monoamine metabolites in successive samples of spinal fluid.Acta Neurol Scand. 1981; 63: 247
- A comprehensive psychopathological rating scale.Acta Psychiatr Scand Suppl. 1978; 271: 5
- CSF monoamine metabolites in melancholia.Acta Psychiatr Scand. 1984; 69: 201
- Immunoreactive parathyroid hormone, calcium and magnesium in human cerebrospinal fluid.Acta Endocrinol. 1984; 106: 227
- Cerebrospinal fluid magnesium and calcium related to amine metabolites, diagnosis, and suicide attempts.Biol Psychiatry. 1985; 20: 163
- Stimulation of parathyroid hormone secretion by EDTA-infusion—A test for the differential diagnosis of hypercalcaemia.Acta Endocrinol. 1986; 111: 498
- Hyperparathyroidism: Neuropsychiatrie manifestations.Psychosomatics. 1985; 26: 597
- Calcium: Bivalent cation in the bivalent psychoses.Biol Psychiatry. 1979; 14: 295
- Calcium and electroconvulsive therapy of severe depressive illness.Biol Psychiatry. 1977; 12: 5
- Intracellular calcium ions in affective disorders: A review and a hypothesis.Biol Psychiatry. 1983; 18: 781
- Mental changes associated with hyperparathyroidism.Am J Psychiatry. 1975; 132: 129
- Divalent ions in blood and cerebrospinal fluid: Effect of hypercalcemia, hyperphosphatemia, renal failure and parathyroid hormone.Adv Exp Med Biol. 1980; 128: 289
- A study of cerebrospinal fluid calcium and magnesium in depression.J Assoc Physicians India. 1975; 23: 311
- Primary hypeiparathyroidism: Incidence, morbidity and potential economic impact in a community.N Engt J Med. 1980; 302: 189
- Primary hypeiparathyroidism. Laboratory and clinical data in 73 cases.JAMA. 1975; 233: 519
- Cerebrospinal fluid calcium: Clinical correlates in psychiatric and seizure disorders.in: Wood JH Neurobiology of CSF. Plenum Press, New York1980: 743-749
- Psychiatric symptomatology in patients with primary hyperparathyroidism.Ups J Med Sci. 1986; 91: 77
- Primary hyperparathyroidism in patients with organic brain syndrome.Acta Med Scand. 1986; 219: 91
- Neuropsychiatrie disorders in primary hyperparathyroidism.Arch Neurol. 1964; 10: 387
- Primary hyperparathyroidism: Clinical and biochemical features.Medicine. 1974; 53: 127
- Reliability of the CPRS between the disciplines of psychiatry, general practice, nursing and psychology in depressed patients.Acta Psychiatr Scand Suppl. 1978; 271: 29
- Neuromuscular disease in primary hyperparathyroidism.Ann Intern Med. 1974; 80: 182
- Psychiatric disorders in primary hyperparathyroidism.J Clin Endocrinol Metab. 1968; 28: 1491
- Is parathyroidectomy of benefit in primary hyperparathyroidism?.Q J Med. 1985; 54: 241
- Neurotransmittors and CNS disease: Depression.Lancet. 1982; ii: 1259
- Long-term effect of surgical treatment on the symptoms of primary hyperparathyroidism.Ann Clin Res. 1985; 17: 141
- Monoamine metabolites in CSF and suicidal behaviour.Arch Gen Psychiatry. 1981; 38: 631
- CSF monoamine metabolites of depressed patients during illness and after recovery.Acta Psychiatr Scand. 1984; 69: 333
Received in revised form: April 13, 1987
Received: November 26, 1986
☆Supported by a grant from Fredrik and Ingrid Thurings Foundation, Stockholm, and the Swedish Medical Research Council.
© 1988 Published by Elsevier Inc.