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Abstract
Covariance of brain electrical activity (EEG), plasma adrenocorticotrophic hormone
(ACTH) and cortisol levels, and mood states were determined for healthy adult men
during the first 2 hr after ingestion of ethanol or ethanol placebo under controlled
doubleblind conditions. Analysis of integrated plasma ACTH and cortisol levels at
5-min intervals, EEG power spectral analysis during consecutive 2-min epochs, and
continuous assessment of mood states with a nonverbal instrumental device were carried
out during the ascending phase of the blood ethanol curve. Ethanol induced rapid changes
in brain electrical activity and plasma ACTH levels that were significantly correlated
with subjective perception of changes in mood. The paroxysmal short epochs of euphoria
associated with electroencephalographic and ACTH responses during the ascending phase
of the blood ethanol curve may reflect physiological concomitants of pharmacological
and behavioral reinforcers that enhance risk for perpetuation of drinking and alcohol
abuse.
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Article info
Publication history
Received in revised form:
February 7,
1987
Received:
February 7,
1987
Footnotes
☆Supported in part by Grant DA00064 from the National Institute on Drug Abuse and Grant AA06252 from the National Institute on Alcohol Abuse and Alcoholism.
Identification
Copyright
© 1988 Published by Elsevier Inc.
