Advertisement
Research Article| Volume 23, ISSUE 2, P129-135, January 15, 1988

Memory impairment in schizophrenic patients with tardive dyskinesia

      This paper is only available as a PDF. To read, Please Download here.

      Abstract

      Memory functioning was contrasted in 40 schizophrenic patients with and without tardive dyskinesia (TD). Visual and verbal memory tests were used to investigate specific types of impairments. The presence of TD was ascertained using the Abnormal Involuntary Movement Scale (AIMS). TD patients scored significantly lower than non-TD patients on two measures of visual learning, though no differences were found for verbal learning or immediate recall. These results are consistent with previous reports that schizophrenic patients with TD demonstrate impaired cognitive functioning. They also raise the possibility that the neurochemical and structural changes underlying TD may produce specific deficits in memory for visual materials. In addition, a significant relationship was found between total score on the Brief Psychiatric Rating Scale (BPRS) and performance on all of the test measures included in the cognitive test battery. This demonstrates the importance of attending to the overall level of schizophrenic symptomatology when evaluating results from experimental learning tasks.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Biological Psychiatry
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Amaducci I
        • Sorbi S
        • Albanese A
        • Gianott C
        Choline acetyltransferase (chAT) activity differs in right and left human temporal lobes.
        Neurology. 1981; 31: 799-805
        • American Psychiatric Association
        Diagnostic and Statistical Manual of Mental Disorders.
        3rd ed. American Psychiatric Association, Washington, DC1980
        • Asnis G
        • Leopold MA
        • Duvoisin RC
        • Schwartz AH
        A survey of tardive dyskinesia in psychiatric outpatients.
        Am J Psychiatry. 1977; 134: 1367-1370
        • Baldessarini RJ
        • Tarsy D
        Mechanisms underlying tardive dyskinesia.
        in: Yahr M Proceedings of the Association of Research in Nervous and Mental Disease. Raven Press, New York1976
        • Baldessarini RJ
        • Cole JO
        • Davis JM
        • Gardos G
        • Proskorn SH
        • Simpson GM
        • Tarsy D
        Task Force Report of the American Psychiatric Association on Late Neurological Effects of Antipsychotic Drugs.
        American Psychiatric Association, Washington, DC1980
        • Benton AL
        A multiple choice type of the visual retention test.
        Arch Neurol Psychiatry. 1950; 64: 699-707
        • Benton AL
        Revised Visual Retention Test: Clinical and Experimental Applications.
        4th ed. Psychological Corporation, New York1974
        • Berent S
        Psychopathology and other behavioral considerations for the clinical neuropsychologist.
        in: Handbook of Clinical Neuropsychology. vol. 2. John Wiley and Sons, New York1986
        • Brainin M
        • Reisner TH
        • Zeitlhofer J
        Tardive dyskinesia: Clinical correlation with computed tomography in patients aged less than 60 years.
        J Neurol Neurosurg Psychiatry. 1983; 46: 1037-1040
        • Crovitz HH
        • Zener K
        A group test for assessing hand and eye dominance.
        Am J Psychiatry. 1962; 45: 271-276
        • Edwards H
        The significance of brain damage in persistent oral dyskinesia.
        Br J Psychiatry. 1970; 116: 271-275
        • Fumuyiwa OO
        • Eccleston D
        • Donaldson AA
        • Guiside RF
        Tardive dyskinesia and dementia.
        Br J Psychiatry. 1979; 135: 500-504
        • Gelenberg AJ
        Computerized tomography in patients with tardive dyskinesia.
        Am J Psychiatry. 1976; 133: 578-579
        • Guy W
        ECDEU Assessment Manual for Psychopharmacology.
        in: Department of Health, Education and Welfare, Washington, DC1976: 34-37
        • Heaton RK
        • Crowley TJ
        Effects of psychiatric disorders and their somatic treatments on neuropsychological test results.
        in: Handbook of Clinical Neuropsychology. John Wiley and Sons, New York1981
        • Jeste DV
        • Wagner RL
        • Weinberger DR
        • Rieth KG
        • Wyatt RJ
        Evaluation of CT scans in tardive dyskinesia.
        Am J Psychiatry. 1980; 137: 247-248
        • Jeste DV
        • Weinberger DR
        • Zalcman S
        • Wyatt RJ
        Computed tomography in tardive dyskinesia.
        Br J Psychiatry. 1980; 136: 606-608
        • Jose C
        • Mallaya A
        • Mehta D
        • Evanson R
        • Holland R
        Iatrogenic morbidity in patients taking depot fluphenazine.
        Am J Psychiatry. 1979; 136: 976-977
        • Kane JM
        • Smith JM
        Tardive dyskinesia.
        Arch Gen Psychiatry. 1982; 39: 473-481
        • Kane JM
        • Woener M
        • Weinhold P
        • Wegner J
        Results from prospective study of tardive dyskinesia development: Preliminary findings over a 2-year period.
        Psychopharmacol Bull. 1982; 18: 82-83
        • Lezak MD
        Neuropsychological Assessment.
        2nd ed. Oxford University Press, New York1983
        • Losonczy MF
        • Song IS
        • Mohs RC
        • Small NA
        • Davidson M
        • Johns CA
        • Davis KL
        Correlates of lateral ventricular size in chronic schizophrenia.
        Am J Psychiatry. 1986; (in press).
        • McGraw-Hill
        SPSS Users Guide. McGraw-Hill, Chicago1983
        • Myslobodsky MS
        • Tomer MA
        • Holden MB
        • Kempler S
        • Sigal M
        Cognitive impairment in patients with tardive dyskinesia.
        J Nerv Men Dis. 1985; 173: 156-160
        • Oke A
        • Keller R
        • Mefford I
        • Adams RN
        Lateralization in norepinephrine in human thalamus.
        Science. 1978; 200: 1411
        • Overall JE
        • Gorham DR
        The Brief Psychiatric Rating Scale.
        Psychol Rep. 1962; 10: 799-812
        • Rosen WG
        • Mohs RC
        • Davis KL
        A new rating scale for Alzheimer's disease.
        Am J Psychiatry. 1984; 141: 1356-1364
        • Wechsler D
        A standardization memory scale for clinical use.
        J Psychol. 1945; 19: 87-95
        • Wegner JT
        • Kane JM
        • Weinhold P
        • Woener M
        • Kinon B
        • Lieberman J
        Cognitive impairment in tardive dyskinesia.
        Psychiatry Res. 1985; 16: 331-337
        • Wolf ME
        • Ryan JJ
        • Mosniam AD
        Cognitive functions in tardive dyskinesia.
        Psychol Med. 1983; 13: 671-674