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Abstract
Defatted breast milk from women with postpartum psychosis and from healthy lactating
women was analyzed by high-resolution gel permeation chromatography as well as by
sodium dodecyl sulfate (SDS) and urea polyacrylamide gel electrophoresis. The gel
permeation procedure allowed quantitative analysis of milk proteins (including betacasein)
with minute amounts of defatted milk (10–15 μl). By electrophoresis, further characterization
of the protein pattern, including the beta-casein fraction, was obtained. Milk samples
from five control and seven psychotic subjects were analyzed. The concentration of
the beta-casein-containing peak was significantly lower in milk samples from the psychotic
group by both chromatography and electrophoresis. These lower levels of beta-casein
may result from a higher rate of enzymatic degradation generating i.a. peptides with
opioid activity, as shown earlier in plasma and CSF of women with postpartum psychosis.
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Article info
Publication history
Received in revised form:
April 18,
1987
Received:
February 9,
1987
Footnotes
☆Supported by Swedish Medical Council Grant 5095 and by Amundson's Fund.
Identification
Copyright
© 1988 Published by Elsevier Inc.
