Brief report| Volume 23, ISSUE 8, P833-836, April 15, 1988

Download started.


Measurement of 3H-serotonin uptake in blood platelets in major depressive episodes

      This paper is only available as a PDF. To read, Please Download here.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Biological Psychiatry
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Angel I
        • Paul SM
        Inhibition of synaptosomal 5-(3H)hydroxytryptamine uptake by endogenous factor(s) in human blood.
        FEBS Lett. 1984; 171: 280
        • APA Committee on Nomenclature and Statistics
        ed 3. Diagnostic and Statistical Manual of Mental Disorders. APA, Washington, DC1980
        • Barbaccia ML
        • Gandolfi O
        • Chuang DM
        • Costa E
        Modulation of neuronal serotonin uptake by a putative endogenous ligand of imipramine recognition sites.
        in: Proc Nat Acad Sci USA. 16. 1983: 5134
        • Buczko W
        • Invemizzi R
        • de Gaetano G
        High pressure liquid chromatography microassay for platelet serotonin.
        Thrombostas Haemostas (Stuttgart). 1984; 51: 131
        • Coppen A
        • Prange AJ
        • Whybrow PC
        • Noguera R
        Abnormalities of indole amines in affective disorders.
        Arch Gen Psychiatry. 1972; 26: 474-478
        • Coppen A
        • Swede C
        • Wood K
        Platelet 5-hydroxytryptamine accumulation in depressive illness.
        Clin Chim Acta. 1978; 87: 165-168
        • Gaylord JJ
        • Parker AL
        • Phillips EM
        • Rowsell AR
        Whole blood 5-hydroxytryptamine during treatment of endogenous depressive illness.
        Br J Psychiany. 1973; 122: 597-598
        • Hamilton M
        A Rating Scale for Depression.
        J Neurol Neuroxurg Psychiatry. 1960; 23: 56-62
        • Kaneko M
        • Hayashi A
        • Unne Y
        • Watanabe K
        • et al.
        Serum 5-hydroxytryptamine level in mania depressive illness.
        Fukhusima J Med Sci. 1975; 21: 1-9
        • Le Quan Bui KH
        • Plaisant O
        • Leboyer M
        • Gay C
        • et al.
        Reduced platelet serotonin in depression.
        Psychiatry Res. 1984; 13: 129-139
        • Lingjaerde O
        Blood platelets as a model system for studying the biochemistry of depression.
        in: Usdin E Åsberg M Bertisson L Frontiers in Biochemical and Pharmacological Research in Depression: Advances in Biochemical Psychopharmacology. vol 39. Raven Press, New York1984: 99-111
        • Meltzer HY
        • Arora RC
        • Song P
        Serotonin uptake in blood platelets as a biological marker for major depressive disorders.
        in: Usdin E Biological Markers in Psychiatry and Neurology. Pergamon Press, New York1982: 39-48
        • Munson PJ
        Experimental artefacts and the analysis of ligand binding data: result of a computer simulation.
        J Recept Res. 1983; 3: 249-259
        • Paul SM
        • Rehavi M
        • Skolnick P
        • et al.
        High affinity binding of antidepressants to biogenic amine transport sites in human brain and platelet: Studies in depression.
        in: Post RM Ballenger JC Neurobiology of Mood Disorders. Williams & Wilkins, Baltimore1984: 846-853
        • Pletscher A
        Platelets as models for monoaminergic neurons.
        in: Essays in Neurochemistry and Neuropharmacology. vol. 3. John Wiley & Sons, Chichester, NY1978: 50-101
        • Rausch JL
        • Janowsky DS
        • Risch SC
        • Huey LY
        Physostigmine effects on serotonin uptake in human blood platelets.
        Eur J Pharmacol. 1985; 109: 91
        • Rausch JL
        • Janowsky DS
        • Risch SC
        • Huey LY
        A kinetic analysis and replication of decreased platelet serotonin uptake m depressed patients.
        Psychiatry Res. 1986; 19: 105-112
        • Segonzac A
        • Raisman R
        • Tateishi T
        • Shoemaker H.
        • et al.
        Tryptamine, a substrate for serotonin transporter in human platelets, modifies the dissociation kinetics of (3H)imipramine binding: Possible allosteric interaction.
        J Neurochem. 1985; 44: 349-365
        • Sneddon JM
        Blood platelets as a model for monoamine-containing neurosis.
        in: Progress in Neurobiology. vol 1. Pergamon Press, Oxford1973 (Part 2)
        • Tuomisto J
        • Tukiainen E
        Decreased uptake of 5-hydroxy-tryptamine in blood platelets from depressed patients.
        Nature. 1976; 262: 596-598