This paper is only available as a PDF. To read, Please Download here.
Abstract
The expression of a 70-kD serum fragment of the neural cell adhesion molecule (N-CAM)
in schizophrenia is described. Schizophrenic patients (n = 40) were found to have
statistically significant increases (p < 0.0001) in serum N-CAM levels when compared to normal individuals (n = 26), and this could
not be associated with age or sex. This difference was more marked (p < 0.0001) between type II schizophrenics (n = 13) and normal individuals (n = 26) than when
patients in the overlap group between type I and type II schizophrenia (n = 18) were
compared to normal individuals (p < 0.001). This difference remained significant (p < 0.01) when overlap patients were compared to those of type II schizophrenia. Furthermore,
schizophrenic patients with lower serum N-CAM proved to be better responders to neuraleptic
therapy. We suggest that these elevated serum N-CAM levels reflect an increased synaptic
turnover rate in this psychotic state.
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Biological PsychiatryAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Negative v. positive schizophrenia.Arch Gen Psychiatry. 1982; 39: 789-794
- Development of cerebellar cells in neuron-enriched cultures: Cell surface proteins.Dev Brain Res. 1983; 8: 261-273
- Adhesion among noural cells of the chick embryo. I. An immunological assay for molecules involved in cell-cell binding.J Biol Chem. 1977; 252: 6835-6840
- Alterations in neural cell adhesion molecules during development of different regions of the nervous system.J Neurosci. 1984; 4: 2354-2368
- Brain function, synapse renewal and plasticity.Annu Rev Psychol. 1982; 33: 371-401
- Cell biology of synaptic plasticity.Science. 1984; 225: 1287-1294
- Functional hyperinnervation of cerebral cortex by noradrcnergic neurons results from fetal lesions: Parallels with schizophrenia.Psychopharmacol Bull. 1980; 16: 27-29
- Neural cell adhesion molecule (N-CAM) accumulates in denervated and paralyzed skeletal muscles.in: Proc Natl Acad Sci USA. 82. 1985: 4544-4548
- Distribution of N-CAM in synaptic and extrasynaptic portions of developing and adult skeletal muscle.J Cell Biol. 1986; 102: 716-730
- Molecular pathology of schizophrenia: More than one disease concept.Br Med J. 1980; 280: 66-68
- The search for changes underlying the type II syndrome in schizophrenia.in: Perris C Struwe G Jansson B Biological Psychiatry. Elsevier/North-Holland Biomedical Press, Amsterdam1981: 727-731
- Altered expression ot neuronal cell adhesion molecules induced by nerve injury and repair.J Cell Biol. 1986; 103: 929-945
- Cell adhesion molecules in the regulation of animal form and tissue pattern.Annu Rev Cell Biol. 1986; 2: 81-116
- Diagnostic criteria for use in psychiatric research.Arch Gen Psychiatry. 1972; 26: 57-63
- Neural plasticity in schizophrenia.Schizophr Bull. 1985; 11: 191-229
- Chemical characterisation of a neural cell adhesion molecule purified from embryonic membranes.J Biol Chem. 1982; 257: 7720-7729
- Kinetics of homophilic binding by embryonic and adult forms of the neural cell adhesion molecule.in: Proc Natl Acad Sci USA. 80. 1983: 5762-5766
- Dopamine nerve terminals in the rat limbic cortex: Aspects of the dopamine hypothesis of schizophrenia.Science. 1974; 184: 177-179
- Enzyme-linked immunosorbent assay of the D2-glycoprotein.J Neurochem. 1983; 41: 356-362
- Structural changes in the brain in schizophrenia.in: Iversen SD Psychopharmacology: Recent Advances and Future Prospects. Oxford Medical Publications, Oxford1985: 196-203
- Neuronal membrane D2-protein during rat brain ontogeny.J Neurochem. 1981; 37: 939-946
- Synaptic plasma membrane antigen D2 measured in human cerebrospinal fluid by rocket immunoelectrophoresis. Determination in psychiatric and neurological patients.Scand J Immunol. 1975; 4: 25-30
- Synaptic membrane protein D2 in the cerebrospinal fluid of manic-melancholic patients.Acta Psychiatr Scand. 1977; 56: 50-56
- Blood-brain barrier selectivity and synaptic turnover during delirium tremens and related clinical states.Acta Psychiatr Scand. 1980; 61: 356-364
- Parkinson's disease putamen: Normal concentration of synaptic membrane marker antigens.J Neural Transmiss. 1982; 54: 171-179
- Protein measurement with the Folin reagent.J Biol Chem. 1951; 193: 265-275
- Change in the expression of a neuronal surface protein during development of cerebellar neurones in vivo and in culture.J Neurochem. 1984; 43: 1328-1335
- Perforated synaptic densities: Probable intermediates in synapse turnover.in: Proc Natl Acad Sci USA. 79. 1982: 5718-5722
- Dopamine D2 receptors and schizophrenia.in: Iversen SD Psychopharmacology: Recent Advances and Future Prospects. Oxford Medical Publications, Oxford1985: 216-227
- N-CAM at the vertebrate neuromuscular junction.J Cell Biol. 1985; 101: 285-293
- Differences in the carbohydrate structures of neural cell adhesion molecules from adult and embryonic chicken brains.J Biol Chem. 1982; 257: 11,064-11,069
- Anti-schizophrenic drugs. Membrane receptor sites of action.Biochem Pharmacol. 1977; 26: 1741-1748
- Purification and characterization of the D2 cell adhesion protein. Analysis of the postnatally regulated polymorphic forms and their cellular distribution.Neurochem Res. 1986; 11: 1333-1346
- The biochemistry of schizophrenia—A review.Irish Med J. 1985; 78: 139-143
- Low cerebrospinal fluid concentration of brain-specific protein D2 in patients with normal pressure hydrocephalus.J Neurol Sci. 1983; 62: 59-65
- Adhesion among neural cells of the chick embryo. II. Purification and characterization of a cell adhesion molecule from neural retina.J Biol Chem. 1977; 252: 6841-6845
Article info
Publication history
Received in revised form:
July 27,
1987
Received:
June 3,
1987
Footnotes
☆Supported in part by the Health Research Board and the Schizophrenic Association of Ireland (Cluain Mhuire Branch).
Identification
Copyright
© 1988 Published by Elsevier Inc.
