Research Article| Volume 23, ISSUE 3, P295-311, February 01, 1988

Bilateral brain dysfunction during motor activation in type II schizophrenia measured by EEG mapping

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      In this final electroencephalographic (EEG) mapping study of our series on motor dys-function in neuroleptic-treated schizophrenic patients, we studied 10 right-handed patients with marked negative symptomatology [type II; raw score on the SANS (Munich version) 31.4 ± 5.1]. Simple and multisensorimotor tasks involving both the dominant and non-dominant hand were used for cortical activation. All tasks were referred to resting states obtained after specially designed relaxation procedures. In contrast to predominantly type I patients (SANS-MV score 12.3 ± 4.9) of our previous EEG mapping studies, we found for resting states minor evidence (only) of increased power values in the frequency bands delta and theta. Furthermore, in contrast to signs of “left hemisphere dysfunction” and possible “compensatory right hemisphere overactivation” during motor tasks, which we discussed previously for our type I patients, we found for the type II schizophrenics a bilateral brain dysfunction. This consisted of “nonreactivity” in all frequency bands except alpha, in which, on the contrary, a “hyperreactivity” seemed to be present. In combination with evidence of bilateral hemispheric dysfunction in type II patients reported by other authors using EEG, evoked potentials, regional cerebral blood flow (rCBF) and magnetic resonance imaging (MRI) methods, this suggests that marked bilateral brain dysfunction may be correlated in schizophrenia with a clinical syndrome corresponding rather to the “negative pole” of the positive-negative dimension. In contrast, “left hemisphere dysfunction” and “signs of compensatory overactivation” seem to be linked more to a “positive” symptomatology. Finally, discrepancies of our EEG mapping and rCBF findings during motor activity suggest, speculatively, “uncoupling” between electrical and circulatory parameters in schizophrenia involving both hemispheres in type II, and predominantly the left hemisphere in type I, patients.
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        • Abt K
        Problems of repetitive significance testing.
        Contr clin Trials. 1981; 1: 377-381
        • American Psychiatric Association
        Diagnostic and Statistical Manual of Mental Disorders (DSM-III).
        APA, Washington. DC1980
        • Andreasen NC
        Scale for the Assessment of Negative Symptoms (SANS).
        The University of Iowa, Iowa City1981
        • Andreasen NC
        Negative vs positive schizophrenia: Definition and validation.
        Arch Gen Psychiatry. 1982; 39: 784-788
        • Andreasen NC
        Positive vs negative schizophrenia: A critical evaluation.
        Schiz Bull. 1985; 11: 380-389
        • Andreasen NC
        • Nasrallah HA
        • Dunn V
        • Olson SC
        • Grove WM
        • Ehrhardt JC
        • Coffman JA
        • Crossett HW
        Structural abnormalities in the frontal system in schizophrenia. A magnetic resonance imaging study.
        Arch Gen Psychiatry. 1986; 43: 136-144
        • Andrews HB
        • House AO
        • Cooper JE
        • Barber C
        The prediction of abnormal evoked potentials in schizophrenic patients by means of symptom patterns.
        Br J Psychiatry. 1986; 149: 46-50
        • Brown R
        • Colter N
        • Corsellis JAN
        • Crow TJ
        • Frith CD
        • Jagoe R
        • Johnson EC
        • Marsh L
        Postmortem evidence of structural brain changes in schizophrenia.
        Arch Gen Psychiatry. 1986; 43: 36-42
        • Bleuler E
        Primäre und sekundäre Symptome der Schizophrenie.
        Z Neurol Psychiatry. 1930; 124: 607
        • Buchsbaum MS
        • Kessler R
        • King A
        • Johnson J
        • Cappelletti J
        Simultaneous cerebral glucography with positron emission tomography and topographic electroencephalography.
        in: Pfurtscheller G Jonkman EJ Lopes da Silva FH Brain Ischaemia: Quantitative EEG and Imaging Techniques. Elsevier, Amsterdam1984: 263-269
        • Coger RW
        • Dymond AM
        • Serafetinides EA
        Electroencephalographic similarities between chronic alcoholics and chronic, nonparanoid schizophrenics.
        Arch Gen Psychiatry. 1979; 36: 91-94
        • Crow TJ
        • Corsellis JAN
        • Frith CD
        • Johnstone EC
        • Owen F
        • Bloxham C
        • Ferrier IN
        • Owens DGC
        The search for changes underlying the type II syndrome of schizophrenia.
        in: Perris C Struwe G Jansson B Biological Psychiatry. Elsevier, Amsterdam1981: 727-731
        • Degwitz R
        • Helmchen H
        • Kockott G
        • Mombour W
        Diagnosenschlüssel und Glossar psychiatrischer Krankheiten. Deutsche Ausgabe der internationalen Klassifikation der Krankheiten der WHO, ICD 9th revision.
        Springer, Berlin1980
        • d'Elia GD
        • Jacobsson L
        • vKnorring L
        • Mattison B
        • Mjörndal T
        • Oreland L
        • Perris C
        • Rapp W
        Changes in psychopathology in relation to EEG variables and visual averaged evoked responses (V.AER) in schizophrenic patients treated with penfluridol or thiotixene.
        Acta Psychiatr Scand. 1977; 55: 309-318
        • Delisi LE
        The use of positron emission tomography (PET) to image regional brain metabolism in schizophrenia and other psychiatric disorders: A review.
        in: Handbook of Schizophrenia, Vol 1: The Neurology of Schizophrenia. Elsevier, Amsterdam1986: 309-324
        • Depresseux JC
        • Franck G
        • Sadzot B
        Regional cerebral blood flow and oxygen uptake in human focal epilepsy.
        in: Baldy-Moulinier M Ingvar DH Meldrum BS Cerebral Blood Flow, Metabolism and Epilepsy. Libbey, London1983: 76-81
        • Dewan MJ
        • Pandurangi AK
        • Lee HS
        • Ramachadran T
        • Levy B
        • Boucher M
        • Yozawitz A
        • Major L
        A comprehensive study of chronic schizophrenic patients. I. Quantitative computed tomography: Cerebral density, ventricle and sulcal measures.
        Acta Psychiatr Scand. 1986; 73: 152-160
        • Dieterle DM
        • Albus MI
        • Eben E
        • Ackenheil M
        • Rockstroh W
        First results with the Andreasen scale (Munich version). Assessment of productive and negative symptoms in chronic schizophrenic patients.
        Psychopharmacology. 1986; 19: 96-100
        • Endicott J
        • Spitzer RL
        A diagnostic interview: The Schedule for Affective Disorders and Schizophrenia.
        Arch Gen Psychiatry. 1978; 35: 844-857
        • Etevenon P
        • Ridoux P
        • Rioux P
        • Peron-Magnan P
        • Verdeaux G
        • Deniker P
        Intra- and interhemispheric EEG differences quantified by spectral analysis.
        Acta Psychiatr Scand. 1979; 60: 57-68
        • Flor-Henry P
        • Koles ZJ
        • Howarth BG
        • Burton L
        Neurophysiology studies of schizophrenia, mania, and depression.
        in: Gruzelier J Flor-Henry P Hemisphere Asymmetries of Function in Psychopathology. Elsevier, Amsterdam1979: 481-521
        • Gruzelier JH
        Schizophrenia. Central nervous system signs in schizophrenia.
        in: Handbook of Clinical Neurology. vol 2. Elsevier, Amsterdam1985: 481-521
        • Gruzelier JH
        • Machanda R
        The syndrome of schizophrenia: Relation between electrodermal responses, lateral asymmetries and clinical ratings.
        Br J Psychiatry. 1982; 145: 496-501
        • Guenther W
        • Breitling D
        Predominant sensorimotor area left hemisphere dysfunction in schizophrenia measured by brain electrical activity mapping.
        Biol Psychiatry. 1985; 20: 515-532
        • Guenther W
        • Breitling D
        • Banquet JP
        • Marcie P
        • Rondot P
        EEG mapping of left hemisphere dysfunction during motor performance in schizophrenia.
        Biol Psychiatry. 1986; 21: 249-262
        • Guenther W
        • Moser E
        • Mueller-Spahn F
        • Oefele KV
        • Buell U
        • Hippius H
        Pathological cerebral blood flow during motor function in schizophrenic and endogenous depressed patients.
        Biol Psychiatry. 1986; 21: 889-899
        • Gur RE
        • Skolnick BE
        • Gur RC
        • Caroff S
        • Obrist WD
        • Younkin D
        • Reivich M
        Brain function in psychiatric disorders. I. Regional cerebral blood flow in medicated schizophrenics.
        Arch Gen Psychiatry. 1983; 40: 1250-1254
        • Gur RE
        • Gur RC
        • Skolnick BE
        • Caroff S
        • Obrist WD
        • Resnick S
        • Reivich M
        Brain function in psychiatric disorders. Regional cerebral blood flow in unmedicated schizophrenics.
        Arch Gen Psychiatry. 1985; 42: 329-334
        • Igert C
        • Lairy GC
        térêt prognostique de l'EEG au cours de l'evolution des schizophrenes.
        Clin Neurophysiol. 1962; 14: 183-190
        • Itil TM
        Die Veränderungen der Pentothal-Reaktion bei Psychosen unter der Behandlung mit psychotropen Substanzen.
        in: Proc 3rd World Cong Psychiatry. Univ. of Toronto Press, Toronto1961: 947-950
        • Itil TM
        Elektroencephalographische Studien bei Psychosen und psychotropen Medikamenten.
        Ahmet Sait Matbaasi, Istanbul1964
        • Itil TM
        Computer analysed electroencephalogram to predict the therapeutic outcome in schizophrenia.
        in: Baxter CF Melnechuk T Perspectives in Schizophrenia Research. Raven Press, New York1980
        • Itil TM
        • Itil KZ
        The use of multilead CEEG dynamic brain mapping in the assessment of bioavailability of psychotropic drugs.
        in: Abstr. 15th CINP, San Juan1986
        • Itil TM
        • Saletu B
        • Davis S
        EEG finclings in chronic schizophrenics based on digital period analysis and analog power spectra.
        Biol Psychiatry. 1972; 5: 1-13
        • Itil TM
        • Marasa J
        • Saletu B
        • Davis S
        • Mucciardi AN
        Computerized EEG: Predictor of outcome in schizophrenia.
        J Nerv Ment Dis. 1975; 160: 188-203
        • Jeste DV
        • Kleinman JE
        • Potkin SG
        • Luchins DJ
        • Weinberger DR
        Ex uno multi: Subtyping the schizophrenic syndrome.
        Biol Psychiatry. 1982; 17: 199-222
        • Kammen DP
        • Mann LS
        • Sternberg DE
        • et al.
        Dopamine beta-hydroxylase activity and homovanillic acid in spinal fluid of schizophrenics with brain atrophy.
        Science. 1983; 22: 974-977
        • Kety SS
        The syndrome of schizophrenia: Unresolved questions and opportunities for research.
        Br J Psychiatry. 1980; 136: 421-436
        • Lifshitz K
        • Gradijan J
        Relationships between measures of the coefficient of variation of the mean absolute EEG voltage and spectral intensities in schizophrenics and control subjects.
        Biol Psychiatry. 1972; 5: 149-163
        • Lifshitz K
        • Gradijan J
        Spectral evaluation of the elctroencephalogram: Power and variability in chronic schizophrenic and control subjects.
        Psychophysiology. 1974; 11: 479-490
        • Maurer K
        • Dierks T
        Brain Mapping-topographische Darstellung des EEG und der evozierten Potentiale in Psychiatrie und Neurologie.
        Z EEG-EMG. 1987; 18: 4-12
        • Merrin EL
        • Fein G
        • Floyd TC
        • Yingling CD
        EEG asymmetry in schizophrenic patients before and during neuroleptic treatment.
        Biol Psychiatry. 1986; 21: 455-465
        • Morihisa JM
        • Duffy FH
        • McCarley RW
        BEAM in schizophrenic patients.
        Arch Gen Psychiatry. 1983; 4: 719-728
        • Morihisa JM
        • McAnulty GB
        Structure and function: BEAM and computed tomography in schizophrenia.
        Biol Psychiatry. 1985; 20: 3-19
        • Morstyn R
        • Duffy FH
        • McCarley RW
        Altered topography of EEG spectral content in schizophrenia.
        Electroencephalogr Clin Neurophysiol. 1983; 56: 263-271
        • Nasrallah HA
        • Andreasen NC
        • Coffman JA
        • Oison SC
        • Dunn VD
        • Ehrhardt JC
        • Chapman SM
        A controlled magnetic resonance imaging study of corpus callosum thickness in schizophrenia.
        Biol Psychiatry. 1986; 21: 274-282
        • Pandurangi AK
        • Dewan MJ
        • Boucher M
        • Levy B
        • Ramachandran T
        • Barteil K
        • Bick PA
        • Phelps BH
        • Major L
        A comprehensive study of chronic schizophrenic patients. II. Biological, neuropsychological, and clinical correlates of CT abnormality.
        Acta Psychiatr Scand. 1986; 73: 161-171
        • Raichle ME
        • Grubb Jr, RL
        • Gado MH
        • Eichung JO
        • Ter-Pogossian MM
        Correlation between regional cerebral blood flow and oxidative metabolism. In vivo studies in man.
        Arch Neurol. 1976; 33: 523-526
        • Reynolds GP
        • Czudek C
        Neurochemical laterality of the limbic system in schizophrenia.
        in: Abstr. III Int Symp Cerebr Dynamics. Laterality and Psychopathology, Hakone1986: 61
        • Rosaclini G
        • Ferillo F
        • Rodriguez G
        • Sannita WG
        • Argivo F
        rCBF and quantitative EEG correlations in epileptic patients.
        in: Baldy-Moulinier M Ingvar DH Meldrum BS Cerebral Blood Flow, Metabolism and Epilepsy. Libbey, London1983: 26-31
        • Schneider K
        Primäre und sekundäre Symptome bei der Schizophrenie.
        Fortschr Neurol Neurosurg Psychiatry. 1957; 25: 487-490
        • Spitzer RL
        • Endicott J
        • Robins E
        Research Diagnostic Criteria for a Selected Group of Functional Disorders.
        ed 3. Biometrics Research Division, NY State Psychiatric-Institute, New York1977
        • Theodore WH
        • Porter RJ
        • Dichiro G
        • Sato S
        Correlation of positron emission tomography and electroencephalography in patients with complex partial seizures.
        in: Baldy-Moulinier M Ingvar DH Meldrum BS Cerebral Blood Flow, Metabolism, and Epilepsy. Libbey, London1983: 71-75
        • Weinberger DR
        • Wagner RL
        • Wyatt RJ
        Neuropathological studies of schizophrenia: A selective review.
        Schiz Bull. 1984; 9: 193-212
        • Wolkin A
        • Jaeger J
        • Brrodie JD
        • Wolf AP
        • Fowler J
        • Rotrosen J
        • Gomez-Mont F
        • Cancro R
        Persistence of cerebral metabolic abnormalities in chronic schizophrenia as determined by positron emission tomography.
        Am J Psychiatry. 1985; 142: 564-571
        • Yamamoto YL
        • Ochs R
        • Gloor P
        • Ammann W
        • Meyer E
        • Evans AC
        • Cooke B
        • Sako K
        • Gotman J
        • Feindel WH
        • Diksik M
        • Thompson CJ
        • Robitaille Y
        Patterns of rCBF and focal energy metabolic changes in relation to electroencephalographic abnormality in the inter-ictal phase of partial epilepsy.
        in: Baldy-Moulinier M Ingvar DH Meldrum BS Cerebral Blood Flow, Metabolism, and Epilepsy. Libbey, London1983: 51-62