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Abstract
In this final electroencephalographic (EEG) mapping study of our series on motor dys-function
in neuroleptic-treated schizophrenic patients, we studied 10 right-handed patients
with marked negative symptomatology [type II; raw score on the SANS (Munich version)
31.4 ± 5.1]. Simple and multisensorimotor tasks involving both the dominant and non-dominant
hand were used for cortical activation. All tasks were referred to resting states
obtained after specially designed relaxation procedures. In contrast to predominantly
type I patients (SANS-MV score 12.3 ± 4.9) of our previous EEG mapping studies, we
found for resting states minor evidence (only) of increased power values in the frequency
bands delta and theta. Furthermore, in contrast to signs of “left hemisphere dysfunction”
and possible “compensatory right hemisphere overactivation” during motor tasks, which
we discussed previously for our type I patients, we found for the type II schizophrenics
a bilateral brain dysfunction. This consisted of “nonreactivity” in all frequency
bands except alpha, in which, on the contrary, a “hyperreactivity” seemed to be present.
In combination with evidence of bilateral hemispheric dysfunction in type II patients
reported by other authors using EEG, evoked potentials, regional cerebral blood flow
(rCBF) and magnetic resonance imaging (MRI) methods, this suggests that marked bilateral
brain dysfunction may be correlated in schizophrenia with a clinical syndrome corresponding
rather to the “negative pole” of the positive-negative dimension. In contrast, “left
hemisphere dysfunction” and “signs of compensatory overactivation” seem to be linked
more to a “positive” symptomatology. Finally, discrepancies of our EEG mapping and
rCBF findings during motor activity suggest, speculatively, “uncoupling” between electrical
and circulatory parameters in schizophrenia involving both hemispheres in type II,
and predominantly the left hemisphere in type I, patients.
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Article info
Publication history
Received in revised form:
April 13,
1987
Received:
December 22,
1986
Footnotes
☆Supported in part by the Deutsche Forschungsgemeinschaft, DFG Gu 207/1-1, Bonn, F.R.G.
Identification
Copyright
© 1988 Published by Elsevier Inc.
