Research Article| Volume 23, ISSUE 3, P285-294, February 01, 1988

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Mesolimbic dopaminergic supersensitivity following electrical kindling of the amygdala

  • John G. Csernansky
    Address reprint requests to Dr. J.G. Csernansky, Psychiatry Service. VA Medical Center, Miranda Avenue 4B2 Palo Alto CA 98304.
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, and the Palo Alto VA Medical Center, Palo Alto, CAUSA
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  • Julia Mellentin
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, and the Palo Alto VA Medical Center, Palo Alto, CAUSA
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  • Linda Beauclair
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, and the Palo Alto VA Medical Center, Palo Alto, CAUSA
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  • Leon Lombrozo
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, and the Palo Alto VA Medical Center, Palo Alto, CAUSA
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      Limbic seizures developed in rats following daily electrical stimulation of the basolateral nucleus of the amygdala. Animals were designated as “kindled” after five complete (stage 5) behavioral seizures were observed. A subgroup, designated as “superkindled,” received three additional weeks of electrical stimulations. Kindled rats were significantly subsensitive to the stereotypy-inducing effects of apomorphine, a direct dopamine agonist, compared to controls. Superkindled rats were supersensitive to the effects of apomorphine. However, both kindled and superkindled rats demonstrated an increase in 3H-spiperone βmax values, reflecting dopamine D2-receptor densities, in the nucleus accumbens ipsilateral to the stimulating electrode. The number of interictal spikes recorded from the stimulating amygdaloid electrode during the last week of kindling was correlated with changes in apomorphine sensitivity in individual animals.
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