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A group of 42 patients, ages 55 and above, suffering from major depression were examined in an attempt to isolate clinical variables that would predict response to antidepressants. These patients were part of a placebo-controlled, double-blind study and were given either nortriptyline or phenelzine for 5–7 weeks. There was no significant difference in response rates between patients subclassified as endogenous or nonendogenous by either RDC or Newcastle criteria. No difference in response rates was found between the DSM-III melancholic and nonmelancholic subtypes. Neither drug preferentially treated a sub-type. None of the 21 variables representing symptoms, demographic traits, or characteristics of the depressive illness were found to be significant predictors of antidepressant response.
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Received in revised form: November 24, 1986
Received: June 2, 1986The authors wish to thank Ethel Edelstein and Grete Greene for their excellent secretarial assistance. We would also like to acknowledge the expert technical assistance of David Allen and Brenda Katos for nortriptyline assays, as well as Mary Armour and Joan Kuster for MAO assays.
Supported in part by NIMH Grant MH35196 (A.C.).
© 1987 Society of Biological Psychiatry. Published by Elsevier Inc.