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Abstract
Methylene blue, 15 mg/day, was compared with placebo in treatment of severe depressive
illness. The 3-week trial was designed to avoid bias by placebo response and also
to avoid observer bias. Improvement in patients receiving methylene blue was significantly
greater than in those receiving placebo. Methylene blue at a dose of 15 mg/day appears
to be a potent antidepressant, and further clinical evaluation is essential.
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References
- An inventory for measuring depression.Arch Gen Psychiatry. 1961; 4: 561-569
- Diagnostic criteria for use in psychiatric research.Arch Gen Psychiatry. 1972; 26: 57-63
- Development of a rating scale for primary depressive illness.Br J Soc Clin Psychol. 1976; 6: 278-296
- A new depression scale designed to be sensitive to change.Br J Psychiatry. 1979; 134: 382-389
- Vanadium and affective disorders.in: Gabay GS Harris J Ho BT Metal Ions in Neurology and Psychiatry. Alan R. Liss, New York1985: 91-105
- Possible explanation for therapeutic action of lithium and a possible substitute (methylene blue).Lancet. 1981; ii: 1175-1176
- Catalysis of the reduction of vanadate by psychotropic drugs.Neuropharmacology. 1983; 22: 653-656
- A two-year double-blind crossover trial of the prophylactic effect of methylene blue in manic-depressive psychosis.Biol Psychiatry. 1986; 21: 915-920
Article info
Publication history
Received in revised form:
October 7,
1986
Received:
June 3,
1986
Identification
Copyright
© 1987 Published by Elsevier Inc.
