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Abstract
Gating of auditory sensory responsiveness was examined in 75 psychiatric inpatients
using a conditioning-testing paradigm with the P50 wave of the auditory evoked response,
in which pairs of stimuli are presented to the subject. In previous studies, most
schizophrenics did not decrement the second response to the extent seen in normals.
Acutely ill patients, who were representative of patients admitted to a public university
teaching service and a proprietary hospital, were used to examine the extent to which
diminished sensory gating is found in diagnoses other than schizophrenia. About half
of these patients showed diminished sensory gating that correlated with measures of
severity of illness. The data, taken together with that from other studies using this
paradigm, suggest that diminished sensory gating, like several other psychophysiological
abnormalities, is a trait deficit in schizophrenia, but a state deficit in many other
mental illnesses.
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Article info
Publication history
Received:
August 1,
1986
The assistance of the CPH 8 East-Blue nursing staff, Dr. John J. Kluck, the BPI PAT unit staff, and the University of Colorado Clinical Research Center staff are gratefully acknowledged. Carolyn Zwibecker prepared the manuscript.Footnotes
☆Supported in part by USPHS Grants MH-38321 and RR-00051 and the Veterans Administration Medical Research Service.
Identification
Copyright
© 1987 Published by Elsevier Inc.
