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Abstract
Neuroendocrine functions in depressed patients with major affective disorders were
serially investigated by the Dexamethasone Suppression Test (DST), the thyrotropin-releasing
hormone (TRH) stimulation test, and the plasma TRH-like immunoreactivity (TRH-LI)
measurement. Prior to antidepressant therapy, the sensitivity for nonsuppression to
the DST was 36.0%, whereas that for blunted thyroid-stimulating hormone (TSH) response
to TRH was 28.0%. Both DST nonsuppression and TSH blunting appeared to be state-related
markers for depressed patients. Specifically, a significant increase of maximum TSH
response to TRH after 4 weeks of antidepressant therapy was associated with clinical
improvement. Plasma TRH-LI in depressed patients was significantly lower than that
of healthy controls. It is possible that the lower plasma TRH-LI level is related
to the pathophysiology of some depressed patients with major affective disorders.
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Article info
Publication history
Received in revised form:
October 15,
1986
Received:
June 4,
1986
We would like to thank Dr. H. Naito for his valuable advice. Statistical help was provided by Dr. R. Suga. We are also indebted to T. Yamagiwa and H. Kusano for their technical services. Mrs. M. Tezuka assisted in preparing this manuscript.Footnotes
☆An earlier version of this report was presented at the IVth World Congress of Biological Psychiatry, Philadelphia, PA, 1985.
Identification
Copyright
© 1987 Published by Elsevier Inc.
