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Systemic lithium administration is known to alter the metabolism of myo-inositol and choline, both of which are precursors for phospholipid synthesis. We report that systemic administration also induces a number of changes in the relative levels of rat cerebral cortex phospholipids, including phosphatidylinositol, phosphatidylcholine, sphingomyelin, and phosphatidylethanolamine. As phospholipids play an integral role in the maintenance of biological membranes, these changes are functionally quite significant and may have implications for a better understanding of lithium's therapeutic actions.
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Received in revised form: September 15, 1986
Received: July 21, 1986We gratefully acknowledge the assistance of Edwin Gabbidon. P.R. is supported by NIH Medical Scientist Training Grant 5-T32-GM-07170. This work was also supported by NIH Grant RR02305, by the Ben Franklin Partnership's Advanced Technology Center of S.E. Pennsylvania (University City Science Center), and the University of Pennsylvania Research Fund.
© 1987 Published by Elsevier Inc.