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Abstract
In a series of experiments, rats were given daily injections of 0.3 mg/kg haloperidol
or vehicle 1 hr prior to behavioral testing. In these experiments, when rats were
placed in an illuminated compartment and given the opportunity to enter a darkened
compartment, haloperidol- and vehicle-treated rats initially entered the dark compartment
with similar latencies. With repeated treatments, however, the haloperidol group gradually
took increasingly longer times to enter the dark compartment. Furthermore, when the
drug treatments of the groups were reversed, behavioral performance was dissociated
from the drug state of the animal. Vehicle rats switched to haloperidol entered the
dark compartment much more rapidly than haloperidol rats switched to vehicle. As additional
control procedures, rats were given haloperidol 1 hr posttrial or were given haloperidol
and only placed in the dark compartment. These haloperidol treatments did not differ
from vehicle treatments. The gradual development of long latencies to initiate behavior
and the persistence of this behavior during withdrawal from the haloperidol are consistent
with the establishment of a conditioned drug response. This observation suggests that
conditioning may contribute to the delayed onset of response in the clinical use of
neuroleptic drugs.
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Article info
Publication history
Received in revised form:
August 5,
1986
Received:
November 12,
1985
Footnotes
☆Supported by a Veterans Administration Merit Review Grant.
Identification
Copyright
© 1987 Published by Elsevier Inc.
