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Abstract
The formation of cerebrospinal fluid (CSF) after chronic treatment with imipramine
(IMI), lithium (Li), or electroshock (EST) was studied in urethane-anesthetized rats
by ventricular-cisternal perfusion with 14C-inulin. Effects of these treatments on
the removal of 45Ca from the cerebroventricular perfusate were also studied. The mean
value for CSF formation in control rats was 2.6 ± 0.2μ/min. EST and IMI both increased CSF formation significantly ( + 38% and +19%, respectively).
Li caused a significant decrease ( − 19%). Endogenous removal of 45Ca was by bulk
CSF absorption to blood and by uptake to brain. In control animals, the uptake by
brain accounted for 42% of the total endogenous removal at the steady state. Each
of the applied treatments resulted in a significant decrease in the fraction of 45Ca
taken up by the brain (EST 26%, IMI 33%, Li 29%). Thus, although chronic EST or IMI
resulted in an effect opposite to that obtained by Li on CSF formation, all three
treatments appear to act similarly in reducing calcium passage from the cerebroventricular
compartment to brain tissue.
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Article info
Publication history
Received in revised form:
January 7,
1987
Received:
October 3,
1986
Footnotes
☆Supported in part by NIMH Grant MH 33690.
Identification
Copyright
© 1987 Published by Elsevier Inc.
