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Abstract
The effects of acute administration of reduced haloperidol (RHAL) on homovanillic
acid (HVA) in the caudate and prefrontal cortex were examined in rats. Haloperidol
(HAL) was used as a reference compound. Concentrations of HVA and HAL were measured
by HPLC/ECD. The maximal HVA response time was 3 hr after the injection, in both caudate
and prefrontal cortex, for both RHAL and HAL. The potency of RHAL in the elevations
of HVA in the caudate and prefrontal cortex was only about one-third to one-fifth
that of HAL. The concentrations of HAL in the prefrontal cortex and caudate after
RHAL administration were just about one-third to one-fifth those after HAL administration.
These results suggest that less antidopaminergic activity of RHAL in this neuroleptic
test might be explained by the lesser conversion of RHAL to HAL.
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Article info
Publication history
Received in revised form:
February 27,
1987
Received:
August 25,
1986
The authors wish to thank Y.-L. Yeh for statistical analysis, S.-J. Lin for typing the manuscript, and H.-F. Chang and S.-S. Chao for technical assistance.Footnotes
☆Supported in part by Grants NSC 74-0606-B109-02 and NSC 75-0606-B109-02 from the National Science Council.
Identification
Copyright
© 1987 Published by Elsevier Inc.
