This paper is only available as a PDF. To read, Please Download here.
Abstract
Seven normal subjects received 0.25 mg/kg D-amphetamine orally, both after an overnight
fast and again after a standard breakfast. Plasma levels, subjective and cardiovascular
effects, and observer-rated activation were assessed hourly for 5 hr. Food did not
affect amphetamine levels. Plasma levels peaked at 2–3 hr. Maximum cardiovascular
effects generally occurred at 1 hr, whereas maximum behavioral and subjective effects
occurred at 2 hr. Subjective and behavioral effects declined thereafter, in spite
of substantial amphetamine levels. A separate group of 8 subjects received 0.5 mg/kg
D-amphetamine orally. Plasma levels, subjective and cardiovascular effects, and activation
ratings were assessed hourly for 4 hr. Maximum plasma levels were approximately twice
those seen in the first group. In this case, plasma levels peaked at 3–4 hr; blood
pressure and subjective and behavioral effects were all maximal at 2–3 hr and were
declining by 4 hr, in spite of stable or rising plasma levels.
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Biological PsychiatryAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Psychoses induced by central nervous system stimulants and related drugs.in: Creese I Stimulants: Neurochemical Behavioral and Clinical Perspectives. Raven Press, New York1983
- Amphetamine abuse in New York City, 1966–1968.Semin Psychiatry. 1969; 1: 195-207
- CNS stimulants as tools in the study of schizophrenia.Trends Neuro Sci. 1984; 7: 388-390
- The Manic State Rating Scale. Scale construction, reliability and validity.Arch Gen Psychiatry. 1971; 25: 256-262
- Amphetamine addiction and disturbed sexuality.Arch Gen Psychiatry. 1961; 4: 74-78
- Clinical pharmacology of d-amphetamine in hyperactive children.in: Gottschalk LA Pharmacokinetics of Psychoactive Drugs. Further studies. Spectrum, New York1979: 137-153
- Plasma levels of d-amphetamine on hyperactive children, Serial behavior and motor responses.Psychopharmacology. 1979; 62: 133-140
- Behavior and motor response in hyperactive children and plasma amphetamine levels following a sustained release preparation.J Am Acad Child Psychiatry. 1980; 19: 225-239
- Acute psychologic and neuroendocrine effects of dextroamphetamine and methylphenidate.Psychopharmacology. 1978; 58: 189-195
- Methylphenidate hydrochloride given with or before breakfast: II. Effects on plasma concentration of methylphenidate and ritalinic acid.Pediatrics. 1983; 72: 56-59
- A new distinction between the euphoric and antidepressant effects of methylamphetamine.Br J Psychiatry. 1978; 133: 416-423
- Amphetamine Psychosis Maudsley Monograph No. 5. Oxford University Press, London1958
- The stimulating action of benzedrine sulfate.JAMA. 1937; 108: 1770-1776
- The neuroendocrine and behavioral response to dextroamphetamine in normal individuals.Biol Psychiatry. 1984; 19: 1305-1315
- Amphetamine psychosis: I. Description of the individuals and process.J Nerv Ment Dis. 1967; 144: 273-283
- d-Amphetamine response and Dexamethasone Suppression Test as predictors of outcome in unipolar depression.Biol Psychiatry. 1983; 18: 499-504
- Dextroamphetamine response as a predictor of improvement with tricyclic therapy in depression.Arch Gen Psychiatry. 1971; 25: 247-255
- Biochemistry and behavior: Some central actions of amphetamine and antipsychotic drugs.Annu Rev Psychol. 1976; 27: 91-127
- The use of methylphenidate in depressed patients after cardiac surgery.J Clin Psychiatry. 1984; 45: 82-84
- Response of depressed patients to methylamphetamine.Br J Psychiatry. 1974; 125: 496-499
- Physiologic, subjective, and behavioral effects of amphetamine, methamphetamine, ephedrine, phenmetrazine, and methylphenidate in man.Clin Pharmacol Ther. 1971; 12: 245-258
- Effect of benzedrine sulfate on mood and fatigue in normal and neurotic persons.Arch Neurol Psychiatry. 1936; 36: 816-822
- Amphetamine: Biochemical and behavioral actions in animals.in: Handbook of Psychopharmacology, Vol II. Stimulants. Plenum, New York1978: 41-98
- The central action of beta-aminopropylbenzene (benzedrine) clinical observations.JAMA. 1937; 108: 528-531
- Pharmacogenetics of d-amphetamine in man.in: Gershon E Matthysse S Breakfield XO Ciaranello RD Genetic Research Strategies for Psychology and Psychiatry. Boxwood Press, Pacific Grove, CA1981: 257-268
- Hypertension produced with benzedrine its psychological accompaniments.Lancet. 1936; i: 1107-1109
- Cocaine psychosis: A continuum model.Am J Psychiatry. 1975; 132: 225-231
- The effects of cocaine on depressed patients.Am J Psychiatry. 1974; 131: 511-517
- The methylphenidate test for differentiating desipramine-responsive from nortriptyline-responsive depression.Am J Psychiatry. 1983; 140: 212-214
- Heterogeneity of amphetamine response in depressed patients.Am J Psychiatry. 1981; 138: 1302-1307
- Comparative effects of d-amphetamine, l-amphetamine and methylphenidate on mood in man.Psychopharmacology. 1977; 53: 1-12
- Acute response to methylphenidate as a predictor of outcome with TCA's in the elderly.J Clin Psychiatry. 1985; 46: 466-469
- Prediction of imipramine antidepressant response by a one-day d-amphetamine trial.Am J Psychiatry. 1978; 135: 1179-1184
- Drug-induced mood changes in man. 2. Personality and reactions to drugs.JAMA. 1985; 157: 1113-1119
Article info
Publication history
Received in revised form:
February 23,
1987
Received:
July 1,
1986
Identification
Copyright
© 1987 Published by Elsevier Inc.
