Research Article| Volume 22, ISSUE 9, P1097-1106, September 1987

Erythrocyte acetylcholinesterase in psychiatric disorders and controls

  • Juergen Fritze
    Address reprint requests to Dr. J. Fritze, Department of Psychiatry, University of Wuerzburg, Fuechsleinstrasse 15 D-8700 Wuerzburg, F.R.G..
    From the Department of Psychiatry, University of Wuerzburg, Wuerzburg, Federal Republic of Germany
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  • Helmut Beckmann
    From the Department of Psychiatry, University of Wuerzburg, Wuerzburg, Federal Republic of Germany
    Search for articles by this author
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      Acetylcholinesterase (AChE)from erythrocytes was solubilized by Triton X-100. Size and charge heterogeneity of AChE was investigated by polyacrylamide gel electrophoresis (PAGE) and isoelectric focusing (IEF) in polyacrylamide gels in the presence of 0.5% (v/v) Triton X-100. There were no interindividual differences in these parameters in 46 psychiatric patients (schizophrenia, major affective disorder, personality disorder, dependency, dementia) and controls. The specific activity of solubilized AChE did not discriminate between controls and patients or between the diagnostic subgroups.
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