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Abstract
Plasma phospholipid essential fatty acids and some of their main metabolites, prostaglandins,
were measured among habitually violent and impulsive male offenders, who all had alcohol
abuse problems, and nonviolent control persons. Linoleic acid (18: 2n-6), the precursor
of the n-6 fatty acids, was below normal in intermittent explosive disorder, but the
dihomogammalinolenic acid (DGLA) (20: 3n-6) and some subsequent n-6 acids were at
the same time elevated among all offenders. Also, a monounsaturate, oleic acid (18:
1n-9) was elevated. The high DGLA correlated with low cholesterol level in intermittent
explosive disorder. The arachidonic acid metabolites PGE2 and TxB2 were elevated in violent antisocial personality. The PGE1/DGLA ratio was low in intermittent explosive disorder. The number of registered violent
crimes and violent suicidal attempts correlated with high phospholipid DGLA values.
The possibility that the high phospholipid DGLA is connected with low free DGLA pool,
and therefore low PGE1 formation, among these offenders is discussed.
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Article info
Publication history
Received in revised form:
December 5,
1986
Received:
July 9,
1986
Identification
Copyright
© 1987 Published by Elsevier Inc.
