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Recent studies demonstrate diminished calcium uptake by cultured skin fibroblasts from Alzheimer patients. To determine if altered calcium homeostasis is also present in tissue taken from Alzheimer patients, calcium homeostasis was assessed in mitogen-stimulated lymphocytes. Calcium uptake by lymphocytes from Alzheimer patients was 10%–15% lower (p < 0.002) than that of lymphocytes from age-matched controls. However, neither superficially bound nor total calcium was altered by Alzheimer's disease. These small differences in uptake may reflect larger differences in cytosolic calcium, in later calciummediated events, or in the response of particular subsets of lymphocytes. Their biological significance remains to be determined.
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Received in revised form: January 7, 1987
Received: March 1, 1986The authors wish to thank Dorthea Brush and Patricia Gleason for their help in obtaining blood samples.
☆Supported in part by the Will Rogers Institute and NIH Grants AG03853 and NS 15125.
© 1987 Published by Elsevier Inc.