Research Article| Volume 22, ISSUE 9, P1079-1086, September 1987

Diminished mitogen-induced calcium uptake by lymphocytes from alzheimer patients

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      Recent studies demonstrate diminished calcium uptake by cultured skin fibroblasts from Alzheimer patients. To determine if altered calcium homeostasis is also present in tissue taken from Alzheimer patients, calcium homeostasis was assessed in mitogen-stimulated lymphocytes. Calcium uptake by lymphocytes from Alzheimer patients was 10%–15% lower (p < 0.002) than that of lymphocytes from age-matched controls. However, neither superficially bound nor total calcium was altered by Alzheimer's disease. These small differences in uptake may reflect larger differences in cytosolic calcium, in later calciummediated events, or in the response of particular subsets of lymphocytes. Their biological significance remains to be determined.
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