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Reversal of normal cerebral asymmetry has been reported to be more frequent in children with higher cortical dysfunction and in schizophrenics, in whom it has clinical significance as well. As there are few studies of bipolar patients, we attempted to determine if significant reversal would be found in a clearly diagnosed sample of bipolar patients. As technical differences may account for varying results, we used two previously reported methods and a modified technique. Correlations of computed tomography (CT) findings with neuropsychological variables (Halstead Reitan Battery and WAIS subtests) were also studied. Bipolars and controls did not differ on any CT measure, nor were there meaningful correlations between asymmetry and neuropsychological variables. If it is confirmed that schizophrenics have increased reversed cerebral asymmetry but bipolars do not, it may point to an important difference, as all other CT abnormalities initially described in schizophrenics are now also noted in bipolar patients.
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Received in revised form: January 13, 1987
Received: October 11, 1986The authors gratefully acknowledge the support of Dr. Stephen Keiffer, Chairman, Department of Radiology, S.U.N.Y. Health Science Center, Syracuse, and Dr. Harvey Taub, Chief of Psychology Research, VA Medical Center, Syracuse.
☆Supported in part by the Hendricks Fund for Medical Research.
© 1987 Published by Elsevier Inc.