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Abstract
Reversal of normal cerebral asymmetry has been reported to be more frequent in children
with higher cortical dysfunction and in schizophrenics, in whom it has clinical significance
as well. As there are few studies of bipolar patients, we attempted to determine if
significant reversal would be found in a clearly diagnosed sample of bipolar patients.
As technical differences may account for varying results, we used two previously reported
methods and a modified technique. Correlations of computed tomography (CT) findings
with neuropsychological variables (Halstead Reitan Battery and WAIS subtests) were
also studied. Bipolars and controls did not differ on any CT measure, nor were there
meaningful correlations between asymmetry and neuropsychological variables. If it
is confirmed that schizophrenics have increased reversed cerebral asymmetry but bipolars
do not, it may point to an important difference, as all other CT abnormalities initially
described in schizophrenics are now also noted in bipolar patients.
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References
- Hemispheric asymmetries and schizophrenia.Am J Psychiatry. 1982; 139: 427-430
- Structural abnormality in the frontal system in schizophrenia.Arch Gen Psychiatry. 1986; 43: 136-144
- Patterns of metabolic activity in the treatment of schizophrenia.Ann Neurol. 1984; 15 (suppl): S166-S169
- Human cerebral asymmetries evaluated by computerised tomography.J Neurol Neurosurg Psychiatry. 1980; 43: 873-878
- Cerebral dominance and cerebral asymmetries on computed tomogram in children.Neurology. 1980; 30: 934
- A comprehensive study of chronic schizophrenic patients.Acta Psychiatr Scand. 1986; 73: 152-160
- Lateralised temporal-limbic dysfunction and psychopathology.Ann NY Acad Sci. 1976; 280: 777-795
- Brain density deficits in chronic schizophrenia.Psychiatry Res. 1980; 3: 179-184
- Structural brain deficits in schizophrenia.Arch Gen Psychiatry. 1981; 38: 1014-1017
- Autism associated with reversed cerebral asymmetry.Neurology(NY). 1978; 28: 348-349
- Developmental dyslexia: Evidence for a subgroup with a reversal of cerebral asymmetry.Arch Neurol. 1978; 35: 90-92
- Computed tomography in schizophrenics and normal volunteers, ii. Cranial asymmetry.Arch Gen Psychiatry. 1982; 39: 771-773
- Morphological cerebral asymmetries of modern man, fossil man, and non-human primates.Ann NY Acad Sci. 1976; 280: 349-366
- Asymmetries of the cerebral hemispheres on computed tomograms.J Comput Assist Tomogr. 1978; 2: 471-476
- A blind, controlled study of occipital cerebral asymmetry in schizophrenia.Psychiatry Res. 1983; 10: 87-95
- Schizophrenia: Evidence for a subgroup with reversed cerebral asymmetry.Arch Gen Psychiatry. 1979; 36: 1309-1311
- Schizophrenia and cerebral asymmetry detected by computed tomography.Am J Psychiatry. 1982; 139: 753-757
- Brain electrical activity mapping (BEAM) in schizophrenic patients.Arch Gen Psychiatry. 1983; 40: 719-728
- Frontal leucotomy size and hemispheric asymmetries on CT scans of schizophrenics with variable recovery.Arch Neurol. 1981; 38: 30-37
- Computed tomography of the brain in patients with acute psychosis and in healthy volunteers.Acta Psychiatr Scand. 1982; 65: 403-414
- Neurophysiology of infantile autism.J Am Acad Child Psychiatry. 1985; 24: 251-262
- Brain stem dysfunction in autism.Arch Gen Psychiatry. 1985; 42: 1018-1025
- Computed tomographic scan of cerebral asymmetries and morphological brain asymmetries.Ann Neurol. 1984; 41: 403-409
- CT scan cerebral hemispheric asymmetry measurements in stroke cases with global aphasia: Atypical asymmetries associated with improved recovery.Cortex. 1983; 19: 371-391
- Differential diagnosis of schizophrenia and manic depressive illness.Arch Gen Psychiatry. 1978; 35: 811-836
- Sulcal prominence in young chronic schizophrenic patients.Psychiatry Res. 1979; 1: 1-8
- Cerebral asymmetry and verbal intellectual deficit.Ann Neurol. 1980; 8: 300-304
- Cerebral asymmetry in children with delayed speech.Denver Child Neurology Society, 1978
- Assessment of Brain Damage: A Neuropsychological Key Approach.Wiley-Interscience, New York1979
- Computerised tomography of the brain in manicdepressive patients—A controlled study.Folia Psychiatr Neurol Jpn. 1982; 36: 137-144
- Unfavourable left-right asymmetries of the brain and autism: A question of methodology.Br J Psychiatry. 1982; 140: 312-319
- Hemispheric asymmetries on computed tomographic scans in schizophrenia and mania.Arch Gen Psychiatry. 1983; 40: 1286-1289
- Asymmetrical volumes of the right and left frontal and occipital lobes of the human brain.Ann Neurol. 1982; 11: 97-100
- Computed tomography in schizophreniform disorder and other acute psychiatric disorders.Arch Gen Psychiatry. 1982; 39: 778-783
- Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia.Arch Gen Psychiatry. 1986; 43: 114-124
- Cerebral laterality and psychiatry: A review of the literature.Am J Psychiatry. 1980; 137: 279-291
Article info
Publication history
Received in revised form:
January 13,
1987
Received:
October 11,
1986
The authors gratefully acknowledge the support of Dr. Stephen Keiffer, Chairman, Department of Radiology, S.U.N.Y. Health Science Center, Syracuse, and Dr. Harvey Taub, Chief of Psychology Research, VA Medical Center, Syracuse.Footnotes
☆Supported in part by the Hendricks Fund for Medical Research.
Identification
Copyright
© 1987 Published by Elsevier Inc.
