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Abstract
Circling behavior is one of the best understood behaviors in animals. It is, for the
most part, dopaminergically mediated and related to asymmetry in dopaminergic activity
between the left and right basal ganglia or left and right frontal cortex. As a rule,
animals rotate toward the hemisphere with lower striatal dopaminergic activity. A
direct technique to find human analogs of circling behavior was not available. We
have developed an automated rotometer with which we can apply the circling rodent
model to humans. Leftprone circling behavior (neglect of right-sided turning) was
found in 10 unmedicated schizophrenic patients, whereas 85 normal controls demonstrated
almost equal right and left turning. These preliminary results may suggest the presence
of a dopaminergic asymmetry in some unmedicated schizophrenic patients ; that is,
right anterior subcortical or cortical structures of the brain may manifest a relative
dopaminergic overactivity compared to left anterior structures in at least some unmedicated
patients with schizophrenia.
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Article info
Publication history
Received in revised form:
January 13,
1987
Received:
November 18,
1986
I thank Drs. Dilip Jeste, Marc Schuckit, J. Christian Gillin, and Clifford Shults and two anonymous reviewers for their comments on earlier versions of the paper, as well as S. Khansarinia and the staff and patients of ward 2-south at the San Diego VA Medical Center.Footnotes
☆Supported in part by a grant from the Veterans Administration.
Identification
Copyright
© 1987 Published by Elsevier Inc.
