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Abstract
The biophysical properties of platelet membranes from five patients with Alzheimer-type
dementia and five neurologically healthy controls, matched for age and sex, were examined
by fluorescence spectroscopy employing the fluorescent probes DPH and TMADPH. The
anisotropy of DPH has previously been observed to be reduced in platelet membranes
of patients with Alzheimer-type dementia. However, Alzheimer's disease was not associated
with a significant change in the flow activation energy at either deep or superficial
regions of platelet membranes. In addition, the temperature-dependent phase transition
observed with TMADPH occurred at the same mean temperature in platelet membranes from
the demented and control groups. Supported by Alzheimer Disease Research Center Grant
AG05133 (G.S.Z): Mental Health Clinical Research Center Grant MH30915 (G.S.Z.); project
grant MH38313 (B.M.C.); and the program grants AG03705 (G.S.Z.), MH36224 (B.M.C.),
and MH31154 (B.M.C.). G.S.Z. was the recipient of ADAMHA Research Scientist Development
Award MH00540.
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Article info
Publication history
Received:
October 22,
1986
Thanks are due to Richard Ulrich, Ph.D., for biostatistical consultation and to Dawna Ruhe for preparation of the manuscript.Identification
Copyright
© 1987 Published by Elsevier Inc.
