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Abstract
Twenty-four-hour urine samples from psychotic and autistic children were precipitated
with benzoic acid at pH 4.3. Fractionation of the aromatic complexes thus formed with
benzoic acid—protein and peptides and uric acid, proteins and peptides on G-25 columns—yielded
filtration patterns that may be of diagnostic value. Peptide material could be extracted
from the formed complexes and refractionated on P2 gels. Increased levels of peptide
material, especially of N-substituted peptides, could be demonstrated. Several bioactive factors (Reichelt et
al. 1981) are under study. Possible etiological factors are discussed, and a working
hypothesis is presented.
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Article info
Publication history
Received in revised form:
April 9,
1986
Received:
September 9,
1985
Footnotes
☆Supported in part by “Folkesanatoriet for nervøse” in Trondheim and the Research Fund for Retarded Children in Oslo.
Identification
Copyright
© 1986 Published by Elsevier Inc.
