Research Article| Volume 21, ISSUE 12, P1175-1188, October 1986

EEG coherence and power in the discrimination of psychiatric disorders and medication effects

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      Electroencephalogram (EEG) coherence (COH) and power measures were included in a series of stepwise discriminant analyses to determine which variables were most sensitive in the differentiation of four psychiatric inpatient groups and two major classes of psychotropic medication. Eight channels of eyes-closed, bipolar EEG activity were recorded from 74 inpatients (paranoid schizophrenics, dysthymics, major affectives receiving tricyclics, neuroleptics, or no medication, and geriatrics). Discriminant analyses were conducted for theta, alpha, and fast beta frequency bands for power variables, COH variables, and the resultant significant power and COH discriminating variables. Without exception, COH measures, usually in the alpha band, were more sensitive than power measures in differentiating the various groups. Results suggested that COH decreases with age, is greatest in paranoid schizophrenics, decreases with neuroleptic medication, and increases with tricyclic antidepressants. Group differences were interpreted in accordance with an arousal model for COH.
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        • Beaumont JG
        • Rugg MD
        The specificity of intrahemispheric EEG alpha coherence asymmetry related to psychological task.
        Biol Psychol. 1979; 9: 237-248
        • Beaumont JG
        • Mayes AR
        • Rugg MD
        Asymmetry in EEG alpha coherence and power: Effects of task and sex.
        Electroencephalogr Clin Neurophysiol. 1978; 45: 393-401
        • Busk J
        • Galbraith GC
        EEG correlates of visual-motor practice in man.
        Electroencephalogr Clin Neurophysiol. 1975; 38: 415-422
        • Berkhout J
        • Walter DO
        Dimensions of voluntary control over interhemispheric coherence of the EEG.
        Electroencephalogr Clin Neurophysiol. 1980; 49 (abstr).: 12P
        • Etevenon P
        • Pidoux B
        • Riioux P
        • Peron-Magnan P
        • Verdeaux G
        • Deniker P
        Intra- and interhemispheric EEG differences quantified by spectral analysis.
        Acta Psychiatr Scand. 1979; 60: 57-68
        • Fenton GW
        • Fenwick PBC
        • Dollimore J
        • Dunn TL
        • Hirsch SR
        EEG spectral analysis in schizophrenia.
        Br J Psychiatry. 1980; 136: 445-455
        • Flor-Henry P
        Lateralized temporal-limbic dysfunction and psychopathology.
        Ann NY acad Sci. 1976; 280: 777-797
        • Flor-Henry P
        On certain aspects of the localization of the cerebral systems regulating and determining emotion.
        Biol Psychiatry. 1979; 14: 677-698
        • Flor-Henry P
        • Yeudall LT
        • Koles ZJ
        • Howarth BG
        Neuropsychological and power spectral EEG investigations of the obsessive-compulsive syndrome.
        Biol Psychiatry. 1979; 14: 119-130
        • Flor-Henry P
        • Koles ZJ
        • Howarth BG
        • Burton L
        Neurophysiological studies of schizophrenia, mania and depression.
        in: Gruzelier J Flor-Henry P Hemisphere Asymmetries of Function in Psychopathology. Elsevier/North Holland, New York1979: 189-222
        • Ford MR
        • Goethe JW
        • Dekker DK
        EEG coherence and power changes during a continuous movement task.
        Int J Psychophysiol. 1986; (in press).
        • French CC
        • Beaumont JG
        A critical review of EEG coherence studies of hemisphere function.
        Int J Psychophysiol. 1984; 1: 241-254
        • Giannitrapani D
        The coherence of the EEG in normal and schizophrenic subjects.
        in: Electroencephalogr Clin Neurophysiol. 49. 1980: 108P (abstr).
        • Giannitrapani D
        • Kayton L
        Schizophrenia and EEG spectral analysis.
        Electroencephalogr Clin Neurophysiol. 1974; 36: 377-386
        • Grindel OM
        Optimal level of EEG coherence and its role in evaluation of the state of human brain function.
        Neurosci Behav Physiol. 1982; 12: 199-206
        • Itil TM
        Qualitative and quantitative EEG findings in schizophrenia.
        Schizophren Bull. 1977; 3: 61-79
        • Itil TM
        • Saletu B
        • Davis S
        EEG findings in chronic schizophrenics based on digital period analysis and analog power spectra.
        Biol Psychiatry. 1972; 5: 1-13
        • Itil TM
        • Saletu B
        • Davis S
        • Allen M
        Stability studies in schizophrenics and normals using computer-analyzed EEG.
        Biol Psychiatry. 1974; 8: 321-335
        • Itil TM
        • Marasa J
        • Saletu B
        • Davis S
        • Mucciardi AN
        Computerized EEG: Predictor of outcome in schizophrenia.
        J Nerv Ment Dis. 1975; 16: 188-203
        • Itil TM
        • Shapiro D
        • Schneider SJ
        • Francis IB
        Computerized EEG as a predictor of drug response in treatment resistant schizophrenics.
        J Nerv Ment Dis. 1981; 169: 629-637
        • Jasper HH
        Report of committee on methods of clinical examination in EEG. Appendix: The ten twenty electrode system of the International Federation.
        Electroencephalogr Clin Neurophysiol. 1958; 10: 371-375
        • Kemali D
        • Vacca L
        • Marciano F
        • Celani T
        • Nolfe G
        • Iorio G
        Computerized EEG in schizophrenics.
        Neuropsychobiology. 1980; 6: 260-267
        • Kirk RE
        Experimental Design: Procedures for the Behavioral Sciences.
        in: Wads worth Publishing, Belmont, CA1968: 66-67
        • Lieber AL
        • Prichep LS
        Diagnosis and subtyping of depressive disorders by quantitative electroencephalography.
        in: Presented at the 138th annual meeting of the APA, Dallas, May 19851985
        • Lieber AL
        • Prichep LS
        Coherence (1.5–7.5 Hz) as a CEEG marker of major depression.
        in: Presented at the 138th annual meeting of the APA, Dallas, May 19851985
        • Lifshitz K
        • Gradijan J
        Spectral evaluation of the electroencephalogram; power and variability in chronic schizophrenia and control subjects.
        Psychophysiology. 1974; 11: 479-490
        • Livanov MN
        • Gavrilova NA
        • Aslanov AS
        Cross correlation between different areas of the human brain during mental work.
        Zh Vyssh Nervn Deyat. 1964; 14 (Russian).
        • Luria AR
        The Working Brain. Basic Books, New York1973: 98 (Cited in)
        • Monakhov K
        • Perris C
        Neurophysiological correlates of depressive symptomatology.
        Neuropsychobiology. 1980; 6: 268-279
        • Morstyn R
        • Duffy FH
        • McCarley RW
        Altered topography of EEG spectral content in schizophrenia.
        Electroencephalog Clin Neurophysiol. 1983; 56: 263-271
        • Perris C
        EEG techniques in the measurement of the severity of depressive syndromes.
        Neuropsychobiology. 1975; 1: 16-25
        • Perris C
        • Monakhov K
        • Von Knorring L
        • Botskarev V
        • Nikiforov A
        Systemic structural analysis of the electroencephalogram of depressed patients.
        Neuropsychobiology. 1978; 4: 207-228
        • Pockberger H
        • Rappelsberger P
        • Petsche H
        • Thau K
        • Kufferle B
        Computer-assisted EEG topography as a tool in the evaluation of actions of psychoactive drugs in patients.
        Neuropsychobiology. 1984; 12: 183-187
        • Rochford JM
        • Weinapple M
        • Goldstein L
        The quantitative hemispheric EEG in adolescent psychiatric patients with depressive or paranoid symptomatology.
        Biol Psychiatry. 1980; 16: 47-54
        • Scammon ME
        • Kennard MM
        • Stroebel CF
        • Glueck BC
        A user-interactive graphics-based computer system for analysis of the EEG.
        Behav Res Meth Instr. 1981; 13: 517-524
        • Schaffer CE
        • Davidson RJ
        • Saron C
        Frontal and parietal electroencephalogram asymmetry in depressed and nondepressed subjects.
        Biol Psychiatry. 1983; 18: 753-762
        • Shagass C
        Brain potential studies of psychopathology.
        Compr Psychiatry. 1980; 21: 483-491
        • Shagass C
        • Roemer RA
        • Straumanis JJ
        Relationships between psychiatric diagnosis and some quantitative EEG variables.
        Arch Gen Psychiatry. 1982; 39: 1423-1435
        • Shagass C
        • Roemer RA
        • Straumanis JJ
        • Josiassen RC
        Psychiatric diagnostic discriminations with combinations of quantitative EEG variables.
        Br J Psychiatry. 1984; 144: 581-592
        • Shaw JC
        Correlation and coherence analysis of the EEG: A selective tutorial review.
        Int J Psychophysiol. 1984; 1: 255-266
        • Shaw JC
        • Brooks S
        • Colter N
        • O'Connor KP
        A comparison of schizophrenic and neuroticpatients using EEG power and coherence spectra.
        in: Gruzelier J Flor-Henry P Hemisphere Asymmetries of Function in Psychopathology. Elsevier/North Holland, Amsterdam1979: 260-264
        • Shaw JC
        • Colter N
        • Resek G
        EEG coherence, lateral preference and schizophrenia.
        Psychol Med. 1983; 13: 199-306
        • Tucker DM
        • Stenslie CE
        • Roth RS
        • Shearer SL
        Right frontal lobe activation and right hemisphere performance.
        Arch Gen Psychiatry. 1981; 38: 169-174
        • Weller M
        • Montague JD
        EEG coherence in schizophrenia: a preliminary study.
        Electroencephalogr Clin Neurophysiol. 1980; 49 (abstr).: 100P-101P