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Abstract
The effects of acute and chronic administration of haloperidol on homovanillic acid
(HVA) in plasma and the brain were examined in the rat. Acute haloperidol treatment
(1 mg/kg) resulted in highly significant elevations in HVA within 30 min and produced
a maximal increase of HVA in 3–6 hr in both plasma and the whole brain. The response
of brain HVA to increasing doses (0.05–30 mg/kg) of haloperidol showed an inverted
U pattern Plasma HVA showed a very flat response to lower doses (⩽ 5 mg/kg) of haloperidol
and a dramatically elevated one to higher doses (⩾ 10 mg/kg). Haloperidol produced
a parallel increase in plasma and brain HVA at lower doses (⩽ 2 mg/kg) only. After
chronic administration of haloperidol for up to 28 days, the response of HVA in plasma
correlated mainly with, but tolerated later than, those in the whole brain and the
olfactory tubercle.
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Article info
Publication history
Received in revised form:
September 30,
1985
Received:
May 20,
1985
The authors wish to thank Miss Y. L. Yeh and Miss R. L. Kuo for statistical analysis. Miss F. S. Yang for typing the manuscript, and Dr. H. G. Hwu for reading and criticizing the manuscript.Footnotes
☆Supported in part by Grant NSC73-0606-B109-02 from the National Science Council.
Identification
Copyright
© 1986 Published by Elsevier Inc.
